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PI-3K/Akt信号传递途径与T细胞反应 被引量：3

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摘要 PI 3K/Akt信号传递途径是T细胞最为重要的信号转导途径之一 ,与T细胞的增殖、分化、活化和抗病毒能力等密切相关 ,其功能主要表现为与CD2 8协同刺激信号一道促进T细胞活化 ;调节周期蛋白和促T细胞增殖因子等表达使T细胞周期正常进行 ;通过调控凋亡信号转导相关激酶活性和凋亡调控因子表达以拮抗P5 3、Fas等诱导的T细胞凋亡以及增强T细胞的抗病毒能力等。
作者 朱光旭 朱利民 余争平
机构地区 中国人民解放军第三军医大学预防医学院军事劳动卫生学教研室 中国人民解放军第三军医大学预防医学院军事劳动卫生学教研室
出处 《国外医学（免疫学分册）》 2004年第2期97-100,共4页 Foreign Medical Sciences(Section of Immunology Foreign Medical Sciences)
关键词 PI-3K/Akt 信号传递 细胞凋亡 CD28
分类号 R392 [医药卫生—免疫学]
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参考文献40

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同被引文献39

  • 1马骏,曼琼,邓毅,杨志军,杨秀娟,李鹏杰.代谢组学在中药七情配伍中的应用研究进展[J].中草药,2020,51(1):276-280. 被引量：8
  • 2聂颖,李昌崇.PI3K信号通路对T细胞发育、活化、增殖、分化及支气管哮喘的作用[J].中华哮喘杂志（电子版）,2011,5(5):348-352. 被引量：6
  • 3王文珊,傅冷西,叶君健.TNF-α信号传导通路的研究进展[J].福建医科大学学报,2005,39(B08):27-31. 被引量：48
  • 4蒋龙翔,俞康.CD28/PI3K在T细胞增殖、活化信号传递中的作用机制[J].现代实用医学,2006,18(3):206-209. 被引量：2
  • 5Varadhachary AS, Perdow C, HU M, et al. Differential ability of T cell subsets to undergo activation-induced cell death [ J ]. Proc Natl Acad Sci USA, 1997, 94 (11 ) : 5778 -5780.
  • 6Sasaki T, Irie-Sasaki J, Jones RG, et al. Function of PI3K gamma in thymocyte development T cell actvation and neutrophil migration [ J ]. Science, 2000, 287(5455): 1040-1047.
  • 7Varadhachary AS, Peter ME, Perdow SN, et al. Selective up-regulation of phosphatidylinositol 3 '-kinase activity in Th2 ceils inhibits caspase-8 cleavage at the death-inducing complex: a mechanism for Th2 resistance from Fas-mediated apoptosis [ J ]. J Immunol, 1999, 163(9) : 4772 -4779.
  • 8Jones RG, Elford AR, Parsons M, et al. CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly [ J ]. J Exp Med, 2002, 196(3) : 335 -348.
  • 9Pandiyan P, Gartner D, Soezeri O, et al. CD152 (CTLA-4) determines the unequal resistance of Thl and Th2 cells against activationinduced cell death by a mechanism requiring PI3 kinase function[ J ]. J Exp Med, 2004, 199(6): 831-842.
  • 10田满荣,杨凤爱.从中医角度浅释衰老的病因[J].陕西中医,2007,28(10):1447-1448. 被引量：1

引证文献3

二级引证文献15

国外医学（免疫学分册）
2004年 第2期

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