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PI-3K/Akt信号传递途径与T细胞反应 被引量：3

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摘要 PI 3K/Akt信号传递途径是T细胞最为重要的信号转导途径之一 ,与T细胞的增殖、分化、活化和抗病毒能力等密切相关 ,其功能主要表现为与CD2 8协同刺激信号一道促进T细胞活化 ;调节周期蛋白和促T细胞增殖因子等表达使T细胞周期正常进行 ;通过调控凋亡信号转导相关激酶活性和凋亡调控因子表达以拮抗P5 3、Fas等诱导的T细胞凋亡以及增强T细胞的抗病毒能力等。
作者 朱光旭 朱利民 余争平
机构地区 中国人民解放军第三军医大学预防医学院军事劳动卫生学教研室 中国人民解放军第三军医大学预防医学院军事劳动卫生学教研室
出处 《国外医学（免疫学分册）》 2004年第2期97-100,共4页 Foreign Medical Sciences(Section of Immunology Foreign Medical Sciences)
关键词 PI-3K/Akt 信号传递 细胞凋亡 CD28
分类号 R392 [医药卫生—免疫学]
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参考文献40

  • 1Appleman LJ, van Puijenbrcek AA, Shu KM, et al. CD28 costimulation mediates down-regulation of p27kipl and cell cycle progression by activation of the PI3K/PKB sig -naling pathway in primary human T cells. [J] .J Immunol, 2002,168(6) :2729-2736.
  • 2Gomppi S, Chiamttini C, Ruaro ME, et al. Gas6 induces growth, beta-catenin stabi -lizafion, and T-cell factor transcriptional activation in contact-inhibited C57 mamm -ary cells. [J]. Mol Cell Biol,2001,21(3) :902-915.
  • 3Sasaki T, Suzuki A, Sasaki J, et al. Phosphoinositide 3-kinases in immunity: lessons from knockout mice. [J] .J Biochem,2002,131 (4) :495-501.
  • 4Kane LP, Mollenauex MN, Xu Z, et al. Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcliption. [J].Mol Cell Biol,2002,22(16):5962-5974.
  • 5Masuyama N, Oishi K, Mori Y, et al. Akt inhibits the orphan nuclear receptor Nut 77 and T-cell apoptosis. [ J ]. J Biol Chem, 2001,276 (35) :32799-33805.
  • 6Lauder A, Castellanos A, Weston K. c-Myb transcription is activated by protein ki -nase B (PKB) following interleukin 2 stimulation of Tcells and is required for PKB-med iated protection from apoptosis. [J]. Mol Cell Bid, 2001,21 (17) : 5797-5805.
  • 7Yoo JK, Cho JH, Lee SW, et al. IL-12 provides proliferation and survival signals to murine CD4 + T cells through phosphatidylinositol 3-kinase/Akt signaling pathway. [J] .J Immunol,2002,169(7) :3637-3643.
  • 8Jones RG, Elfoat AR, Parsons MJ,et al. CD28-dependent activation of protein kina -se B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling comple- x assembly. [J] .J Exp Med,2002,196(3) :335-348.
  • 9Sauvonnet N,Lanbermont l,Van der B P, et al. YopH prevents monocyte chemoa -ttractant protein 1 expression in macrophages and T-cell proliferation through inactiveat -ion of the phosphatidylinositol 3-kinase pathway. [J]. Mol Microbial ,2002,45(3) :805-815.
  • 10Frauwirth KA, Thompson CB. Activation and inhibition d lymphoeytes by costi -mulation. [J] .J Clin Invest,2002,109(3) :295-299.

同被引文献39

  • 1马骏,曼琼,邓毅,杨志军,杨秀娟,李鹏杰.代谢组学在中药七情配伍中的应用研究进展[J].中草药,2020,51(1):276-280. 被引量：9
  • 2聂颖,李昌崇.PI3K信号通路对T细胞发育、活化、增殖、分化及支气管哮喘的作用[J].中华哮喘杂志（电子版）,2011,5(5):348-352. 被引量：7
  • 3王文珊,傅冷西,叶君健.TNF-α信号传导通路的研究进展[J].福建医科大学学报,2005,39(B08):27-31. 被引量：48
  • 4蒋龙翔,俞康.CD28/PI3K在T细胞增殖、活化信号传递中的作用机制[J].现代实用医学,2006,18(3):206-209. 被引量：2
  • 5Varadhachary AS, Perdow C, HU M, et al. Differential ability of T cell subsets to undergo activation-induced cell death [ J ]. Proc Natl Acad Sci USA, 1997, 94 (11 ) : 5778 -5780.
  • 6Sasaki T, Irie-Sasaki J, Jones RG, et al. Function of PI3K gamma in thymocyte development T cell actvation and neutrophil migration [ J ]. Science, 2000, 287(5455): 1040-1047.
  • 7Varadhachary AS, Peter ME, Perdow SN, et al. Selective up-regulation of phosphatidylinositol 3 '-kinase activity in Th2 ceils inhibits caspase-8 cleavage at the death-inducing complex: a mechanism for Th2 resistance from Fas-mediated apoptosis [ J ]. J Immunol, 1999, 163(9) : 4772 -4779.
  • 8Jones RG, Elford AR, Parsons M, et al. CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly [ J ]. J Exp Med, 2002, 196(3) : 335 -348.
  • 9Pandiyan P, Gartner D, Soezeri O, et al. CD152 (CTLA-4) determines the unequal resistance of Thl and Th2 cells against activationinduced cell death by a mechanism requiring PI3 kinase function[ J ]. J Exp Med, 2004, 199(6): 831-842.
  • 10田满荣,杨凤爱.从中医角度浅释衰老的病因[J].陕西中医,2007,28(10):1447-1448. 被引量：1

引证文献3

二级引证文献18

国外医学（免疫学分册）
2004年 第2期

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