2型糖尿病合并脑梗死危险因素的临床研究

Risk factors in patients of type 2 diabetes with cerebral infarction

目的 探讨 2型糖尿病合并脑梗死的危险因素。方法 选取无糖尿病急性并发症的 2型糖尿病患者 5 5 7例 ,其中脑梗死组 2 0 0例 ,无脑梗死组 35 7例 ,测定血压 (Bp)、血甘油三酯 (TG)、血胆固醇 (TCHO)、空腹血糖 (FBG)和血空腹胰岛素 (FBI) ,计算胰岛素敏感指数 (ISI) ,比较两组上述指标的差异。结果 2型糖尿病合并脑梗死组患者Bp、TG明显高于无脑梗死患者 ,分别为Bp(198.3± 2 7.3)mmHg、(16 3.4± 2 5 .4 )mmHg ,TG (1.9± 1.2 )mmol L、(1.4±0 .9)mmol L ,P <0 .0 5 ;而ISI则显著低于糖尿病无脑梗死组患者分别为 (- 0 .0 12± 0 .870 )、(0 .15 6± 0 .80 0 ) ,P <0 .0 5。脑梗死组血TCHO亦高于无脑梗死组为 (5 .6± 1.5 )mmol L、(5 .0± 1.0 )mmol L ,P <0 .0 1。结论 高血压、胰岛素敏感指数降低、高血脂是促使 2型糖尿病合并脑梗死的危险因素。

ObjectiveTo explore the risk factors in type 2 diabetes with cerebral infarction.MethodsSelect 557 diabetes patients without acute complication. Including 200 diabetic patients with cerebral infarction and 357 diabetic patient without cerebral infarction.Blood pressure(BP),blood triglyceride(TG),blood cholesterol(TCHO),fasting blood glucose(FBG),fasting blood insulin(FBI) were measured.Insulin sensibility index(ISI) was calculated.compare the differences of the guideline from the two groups.ResultsBP,TG were higher in diabetic patients with cerebral infarction than in those without cerebral infarction (198.3±27.3)mmHg:(163.4±25.4) mmHg,(1.9±1.2) mmol/L:(1.4±0.9) mmol/L,P<0.05.ISI was lower in diabetic patients with cerebral infarction than in those without cerebral infarction (-0.012±0.870): (0.156±0.800),P<0.05.And TCHO was also higher in diabetic patients with cerebral infarction than in those without cerebral infarction (5.6±1.5) mmol/L:(5.0±1.0) mmol/L, P<0.01.ConclusionHypertension,insulin sensibility index, hyperlipidemia are the risk factors causing cerebral infarction among type 2 diabetes mellitus.