黏附分子在糖尿病并发症发病中的作用及药物干预

Actions and prevention of adhesion molecules in complications of diabete mellitus

黏附分子是在细胞表面表达具有介导细胞间或细胞与细胞外基质相互作用的糖蛋白。近年来的研究表明黏附分子在糖尿病并发症的发生发展中起到了重要作用。一些可以降低黏附分子水平的药物 ,有望为预防和治疗糖尿病血管病变提供新的方向。

Adhesion molecules(AMs) is one kind of glycoproteins expressed on cell surface that can induce interactions between cells or cell and ECM. AMs are indicated to be involved in many chronic complications of diabetes mellitus. Thus, drugs that can decrease levels of AMs are potential new prevention and therapy of diabetic angiopathy.-