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HIV蛋白酶抑制剂与细胞凋亡 被引量:6

HIV protease inhibitors and apoptosis
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摘要 HIV感染人体后造成大量CD4 + T淋巴细胞的凋亡 ,从而破坏免疫系统 ,使机体无法抵抗病毒的入侵 ,导致免疫缺陷。目前的药物靶点都针对病毒本身 ,无法清除体内储存病毒的感染细胞 ,而HIV蛋白酶抑制剂治疗HIV/AIDS患者后可以减少HIV感染引起的细胞凋亡 ,帮助机体恢复免疫功能 ,并且这种作用与其抑制病毒的作用是相独立的 ,这提示了可以通过免疫重建的策略来治疗AIDS。本文综述了HIV蛋白酶抑制剂的研究和发展概况 ,其作用特点以及对细胞凋亡的影响。明确HIV蛋白酶抑制剂与细胞凋亡的关系 ,可以启发新的思路从细胞着手 ,通过恢复机体的免疫能力来对抗病毒 ,从根本上治疗AIDS。 CD4 +T cells from patients with human immunodeficiency virus (HIV) infection undergo apoptosis at an enhanced rate, which leads to immune system damage and invalidation to withstand the virus intrusion. The current antiviral drugs aim at the virus can not clear the chronically infected cells which are the virus reservoirs. But treatment of HIV/AIDS patients with the HIV protease inhibitors (PIs) can reduce the cell apoptosis induced by HIV infection, which can improve immune function, and that is separate from the antiviral effects of PIs. Such suggests that immune reconstruction is a new strategy to cure AIDS. This text reviews HIV PIs research and development, their function characteristics and the effects on cell apoptosis. To define the relationship between HIV PIs and cell apoptosis may inspire new ways of curing the AIDS.-
出处 《中国药理学通报》 CAS CSCD 北大核心 2004年第2期141-145,共5页 Chinese Pharmacological Bulletin
基金 国家 8 63计划 (No 2 0 0 1AA2 15 181) 中国科学院知识创新工程重要方向资助项目 (NoKSCX2 SW 2 16) 中国科学院青年创新基金 云南省自然科学基金 (No 2 0 0 2C0 0 66M 2 0 0 3C0 0 2 2R)资助项目
关键词 HIV蛋白酶抑制剂 细胞凋亡 线粒体 AIDS HIV protease inhibitor apoptosis mitochondria AIDS
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