血瘀证和非血瘀证非小细胞肺癌患者葡萄糖代谢率的研究

Study on Glucose Metabolic Rate in Non-small Cell Lung Cancer Patients with Blood Stasis Syndrome and Non-Blood Stasis Syndrome

目的 :探讨血瘀证与非血瘀证非小细胞肺癌 (non smallcelllungcancer,NSCLC)葡萄糖代谢率的差异。方法 :应用正电子发射型计算机断层显像 (positronemissiontomography ,PET)和功能显像剂18F 2 氟 2 脱氧 D 葡萄糖 (18F 2 fluoro 2 deoxy D glucose ,18FDG) ,对血瘀证和非血瘀证NSCLC患者进行功能代谢显像 ,测定NSCLC患者肺部肿瘤组织中感兴趣区 (regionsofinterest ,ROI) 18FDG的摄取率。结果 :同一组织学类型中 ,血瘀证组的最大和平均18FDG摄取率 (MaximumandMeanStandardizedUptakeValue ,Max SUV、MeanSUV)显著高于非血瘀证组 (P <0 0 1) ;Ⅰ、Ⅱ与Ⅲ期NSCLC之间 ,血瘀证组18FDG摄取率的MaxSUV、MeanSUV高于非血瘀证组 (P <0 0 5 ) ,Ⅳ期NSCLC之间18FDG摄取率显著增强 (P <0 0 1)。结论 :血瘀证NSCLC对葡萄糖的摄取率较非血瘀证NSCLC显著性增强。

Objective:To study the difference of glucose metabolic rate in non-small cell lung cancer (NSCLC) patients with blood stasis syndrome and with non-blood stasis syndrome. Methods:Whole body positron emission tomography (PET) and functional agent 2-〔fluorine-18〕 fluorine-2-deoxy-glucose ( 18FDG) were used to detect the 18FDG uptake value in regions of interest (ROI) in tumor tissue of patients. Results:In patients with same pathologic type, the maximum and mean standardized uptake value (Max SUV and Mean SUV) were significantly higher in the blood stasis group than those in the non-blood stasis group (P<0.01); it also showed the same in patients with NSCLC of phase Ⅰ, Ⅱ and Ⅲ (P<0.05), but the 18FDG uptake rate was obviously enhanced in patients of phase Ⅳ (P<0.01). Conclusion:The glucose uptake in NSCLC patients of blood stasis syndrome was higher than that in those with of non-blood stasis syndrome.