加味玉屏风散对老年慢性支气管炎急性发作期患者T淋巴细胞亚群的影响

Effect of Jiawei Yupingfeng Powder on T-lymphocyte Subsets in Patients with Senile Chronic Bronchitis in Acute Onset Stage

目的:探讨加味玉屏风散对老年慢性支气管炎急性发作期T淋巴细胞亚群的影响。方法:以老年慢性支气管炎急性发作期患者为研究对象,按随机对照原则,在西医常规治疗基础上,将其分为加用加味玉屏风治疗组(治疗组44例)和单纯西医治疗组(对照组40例),进行疗效对比分析,疗程14天,观察T淋巴细胞亚群CD3、CD4、CD8及CD4/CD8比值的变化。结果:治疗组CD3、CD4、CD4/CD8上升(P<0.05),CD8下降(P<0.05),而对照组治疗后T淋巴细胞亚群各指标均无明显变化。两组总有效率比较差异有显著性(P<0.05)。结论:老年慢性支气管炎急性发作期患者存在显著的细胞免疫调节紊乱,加味玉屏风散可通过调节细胞免疫功能增强疗效。

Objective: To explore the effect of Jiawei Yupingfeng Powder (JYP) on T-lymphocyte subsets in patients with senile chronic bronchitis in acute onset stage (SCB-AOS). Methods: Patients, were divided, according to the randomized controlled principle, into two groups, the 44 patients in the treated group and the 40 in the control group. The conventional western medicinal therapy was given to both groups, but to the treated group, JYP was administered additionally. The therapeutic course to them was 14 days. Changes of CD3 , CD4 , CD8 and the ratio of them were observed. Results: Increase of CD3 , CD4 and CD4 /CD8 ( P < 0.05) and decrease of CD8 (P < 0.01) were significantly shown in the treated group after treatment, but no change in the control group. Besides, comparison of the total effective rate in the two groups also showed significant difference (P<0.05). Conclusion: Cellular immune function disturbance exists in patients with SCB-AOS, JYP could enhance the efficacy by way of modulating cellular immune function.