胃癌患者血清血管内皮生长因子检测的临床意义

Clinical significance of serum vascular endothelial growth factor in patients with gastric carcinoma

目的 探讨血清血管内皮生长因子 (s -VEGF)与胃癌临床病理特征的关联及作为胃癌早期诊断指标的可行性。方法 采用酶联免疫吸附法检测 31例胃癌患者术前及术后第一天s-VEGF水平 ,并与同期 13例慢性萎缩性胃炎患者对照。结果 胃癌患者s -VEGF高于对照组 (P <0 .0 5 ) ;s-VEGF随临床分期进展而升高 (P <0 .0 5 ) ;接受根治手术的患者术后较术前下降 (P <0 .0 5 ) ;接受姑息手术者下降不明显 (P >0 .0 5 )。结论 s -VEGF与胃癌的临床病理特征有关 ,术后s -VEGF仍显著增高者需要更积极的治疗。

Objective To investigate the relationship between serum vascular endothelial growth factor(s-VEGF) and clinico-pathological parameters of gastric carcinoma,and to investigate whether s-VEGF can be used as an index for early diagnosis of this disease.Methods The s-VEGF levels were detected in 31 patients with gastric cancer before operation and on the first day after operation respectively by enzyme-linked immunosorbant assay,and the levels of s-VEGF in 13 patients with chronic gastritis were detected simultaneously.Results The levels of s-VEGF in the gastric carcinoma patients were higher than those in control group( P <0.05);s-VEGF increased with clinical stage ( P <0.05);s-VEGF fell on the first day after operation in the patients undergoing radical resection ( P <0.05),while didn't fall in those undergoing palliative resection ( P >0.05). Conclusion The s-VEGF level is associated with clinco-pathological parameters and contributes to genesis and development of gastric carcinoma.The detection of s-VEGF cannot serve as an index for early diagnosis of gastric carcinoma.