乳腺癌C-erbB-2癌基因与雌激素和孕激素受体的关系及其意义

Correlatin between expression of C-erbB-2 oncogene and receptors of estrogen and progestogen and its significance

目的 探讨乳腺癌C -erbB - 2癌基因与雌激素和孕激素受体的关系及其意义。方法 采用免疫组化方法 (二步法 ) ,检测 83例乳腺癌组织中C -erbB - 2、ER、PR的表达。结果 C -erbB - 2、ER、PR在乳腺癌组织中表达阳性率为 5 7 83%、71 0 8%、6 6 2 7%。C -erbB - 2表达 :在ER、PR阴性组高于ER、PR阳性组 (P <0 0 5 ) ;在淋巴结转移组的乳腺癌高于淋巴结未转移组 (P <0 0 5 )。结论 C -erbB - 2与ER、PR联合检测 ,对于乳腺癌患者术后选择个性化化疗具有指导意义 ,也是衡量预后的重要指标。

Objective To investigate the correlation of expression of C-erbB-2 oncogen and receptors of estrogen and progestogen in breast cancer and its clinic significance.Methods We Used immunohistochemical method (two step method)to detect the expression of C-erbB-2 oncogen and receptors of estrogen and progestogen in breast cancer.Results The positive rates of expression of C-erbB-2 oncogen,estrogen receptor and progestogen receptor in breast cancer were 57.83%,71.08% and 66.27%,respectively.The positive rate of expression of C-erbB-2 oncogen was higher in the group with positive expression of estrogen receptor and progestogen receptor than negative group,and in the group with positive lymph node metastasis than non-lymph node metastasis group.The differences were statistically significant ( P <0 05)Conclusion C-erbB-2 oncogen,in combination with estrogen receptorand progestogen receptor,has guiding significance for patients with breast cancer to choose individual chemotherapy after operation and can become an important indicator for judging the prognosis of breast cancer.