盐酸拓普替康治疗卵巢癌16例分析

Recent efficacy and toxicity of potecan hydrochloride on ovarial carcinoma in 16 cases

目的 观察国产盐酸拓普替康 (TPT)治疗卵巢癌的近期疗效和不良反应。方法 对 16例卵巢癌给予单药拓普替康 1 2 5mg/m2 d1～ 5或联合DDP4 0mg/m2 d1,6化疗 ,每 2 1天为一疗程 ,观察疗效和不良反应。结果 国产盐酸拓普替康治疗恶性卵巢癌的近期有效反应率为 37 5 % ,主要的不良反应为骨髓抑制。结论 拓普替康可作为治疗经铂类等药物失败的晚期卵巢恶性肿瘤的有效药物 ,其主要毒副反应为骨髓抑制。每例均需G -CSF支持 ,较高经费支持是其使用受到限制的主要原因。

Objective To study the efficacy and toxicity of Topotecan hydrochloride(TPTHCh)on human ovarian carcinoma.Methods A total of 16 patients with ovarian carcinoma were treated with single agent Topotecan hydrochloride 1.25mg/m2d 1～5 or combined with DDP 40mg/m 2d 1～6 for every three weeks.Results The recent response rate of ovarian carcinoma treated with Topotecan hydrochloride was 37.5%,main side effect was bone marrow depression.Conclusion Topotecan is effective for treating the patients with recurrent ovarian carcinoma who failed with platinumbased regimes,its main side effect is bone marrow depression.G-CSF supported is demanded in every case,superior expense is major cause of application restricted.