摘要
目的 :研究应激性大鼠不同组织中NO浓度的变化与血压的关系。方法 :给SD大鼠间断性足底电刺激并噪声刺激 1 5d ,观察其尾动脉BP的变化和血浆、心耳、心室、血管、肾上腺等组织中NO的浓度变化。结果 :应激组经 1 5d应激后BP显著性升高 ;应激 +L arg (精氨酸 )组应激前后BP变化不明显。应激后血浆中NO的浓度明显降低 ,心耳、心室、血管、肾上腺中的NO几乎难以测出 ,而应激 +L arg组的大鼠经过 1 5d的应激刺激 ,血浆及血管组织中的NO浓度 ,明显升高。心耳、心室、肾上腺中NO的浓度与对照组相比变化不明显。结论 :应激刺激可使BP升高 ,同时血浆、心耳、心室、血管、肾上腺等组织中NO的浓度降低 ,而L arg可抑制BP升高 ,血浆及血管组织中NO浓度增加 ,心耳、心室、肾上腺等组织中NO浓度不降低。
AIM: To study the changes of NO concentrations of different ti ssues in stress rats. METHODS: Add stimulation with experiments employed electric food-shock and noise of busser as stressor for 15 days in SD rats,NO concentrations and BP were measured. RESULTS: In stress group, BPs increased before and after stress stimulation,but decreased levels NO concentrations of plasma, and there was no detectable amounts of NO in auricl e, ventricle, vessel and adrenal. In stress +L-arg group, BPs d id not increase before and after stress stimulation, NO concentrations of plasma increased, but auricle, ventricle, vessel and adrenal maintained the concentrat ions of NO. CONCLUSION: The stress stimulation can increase BP a nd low NO concentration, and L-arg can resist the response.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2004年第2期223-225,共3页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
广东省医学科学技术研究基金资助项目 (№A1 9994 82 )
