肾移植受者口服环孢素A药代动力学的性别差异

Gender difference of pharmacokinetics of oral cyclosporin A in renal transplanted recipients

目的 :研究性别差异对肾移植受者口服环孢素A(CsA)的药代动力学影响。方法 :选择肾移植术后 2wk肝肾功能稳定的患者 41名 ,男 2 1名 ,女 2 0名。口服环孢素剂量 6mg·kg- 1·d- 1,用FPIA方法检测各时间点CsA全血浓度并用 3p87药动学程序拟合CsA药动学参数。结果 :男性和女性口服CsA的主要药动学参数分别为 :tmax(h) :2 .9± 1 .0和 2 .2± 0 .9,Cmax(mg·L- 1) :1 .0± 0 .4和 0 .9± 0 .5 ,Cmin(mg·L- 1) :0 .2 0± 0 .0 9和 0 .1 7± 0 .1 1 ,T1 2 (a) (h) :0 .8±0 .6和 0 .7± 0 .5 ,T1 2 (e) (h) :3 .0± 1 .2和 2 .8±0 .8,AUC0 - 12 (mg·L- 1·h- 1) :5.5± 1 .4和 4 .5± 1 .7,CL F(L·h- 1) :40± 2 5和 47± 35 ,V F(C) (L) :1 59±1 0 8和 1 72± 92。结论 :肾移植患者口服CsA的AUC0 - 12

AIM: To study the effects of gender difference on the pharma co kinetics of oral cyclosporin A in renal transplanted recipients. METHODS : The study included 21 male patients and 20 female patients treated wit h CsA at 6 mg·kg -1 ·d -1 for two weeks. Each patient was involve d in pharmacokinetics of CsA by fluorescence polarization immunoassay. R ESULTS: The pharmacokinetic parameters of CsA in male and female renal t ransplanted recipients were: t max (h): 2.9 ± 1.0 and 2.2 ± 0.9 ; C max ( mg·L -1 ): 1.0 ± 0.4 and 0.9 ± 0.5 ; C min ( mg·L -1 ): 0.20 ± 0.09 and 0.17 ± 0.11 ; T 1/2(a ) (h): 0.8 ± 0.6 and 0.7 ± 0.5 ; T 1/2(e) (h): 3.0 ± 1.2 and 2.8 ± 0.8 ; AUC 0-12 ( mg·L -1 )·h -1 : 5.5 ± 1.4 and 4.5 ± 1.7 ; CL/F( L·h -1 ):40±25 and 47±35, and V/F(C)(L): 159±108 and 172±92, respectively. CONCLUSION: The re is gender difference of pharmacokinetics of oral cyclospori n A in renal transplanted recipients.