p16蛋白在脑胶质瘤中的表达及其临床意义

Expression of p16 protein in brain glioma and its clinical significance

目的 :探讨抑癌基因p16蛋白在脑胶质瘤发生、分化过程中的作用及其与预后的关系经。方法 :采用免疫组化的方法检测 5 4例脑胶质瘤患者病理标本中的p16蛋白 ,分析p16蛋白的缺失与病理分级、患者预后之间的关系。结果 :全组共有 2 9例 (5 3.7% )标本p16蛋白表达阴性 ,Ⅲ、Ⅳ级胶质瘤的p16蛋白的阴性率明显高于Ⅰ、Ⅱ级 (P <0 .0 5 )。p16蛋白表达阳性患者的复发率明显低于p16蛋白表达阴性者 (P <0 .0 5 ) ,分别为 2 0 .0 %和 5 5 .2 %。结论 :p16蛋白的缺失与脑胶质瘤的恶性程度有关 ,恶性程度越高 ,p16蛋白的缺失率越高 ;p16蛋白的缺失与预后相关 ,其缺失率越高 ,患者复发率越高。

Objective: To investigate the correlation of p16 expression with the proliferation, malignant progression and prognosis of brain glioma. Methods: 54 patients of brain glioma were examined with immunohistochemistry. The relationship between the expression of p16 protein and the pathological grade and the recurrence of the tumor were analyzed. Results :There were 29 cases (53.7%) that the expression of p16 protein was negative. The negative rate of Ⅰ, Ⅱ,Ⅲ,Ⅳ pathological grade was 20%, 35.7%,63.6% and 69.2% respectively. The negative rate of Ⅲ and Ⅳ grade was significantly higher than Ⅰand Ⅱ grade. (P<0.05). The recurrence rate of patients with positive expression of p16 protein(20.0% ) was significant lower than the those with negative expression(55.2%) .Conclusion:The loss or mutation of p16 gene is one of the reasons of the malignant progression in brain glioma. The immunohistochemical detection of p16 protein acts as a prognosis index for brain glioma.