β-1,6葡聚糖纤维素的临床应用

The effect of clinical application of β-1,6 glucosan on blood lipid and blood glucose

目的 :观察以 β 1,6葡聚糖为主要成分的纤维素对血脂和血糖的调节作用。 方法 :根据相应的标准从体检人员中筛选出高脂血症、糖耐量减低和便秘患者。高脂血症患者每天服用纤维素 8g ,其间不控制饮食 ,不服降脂药物 ,观察 1个月 ,测定观察前后患者血清甘油三酯和胆固醇水平 ;糖耐量减低者分为三组 ,均不服用降糖药物 :对照组只进行一次饮食控制教育 ;而饮食控制组每 2个月进行一次膳食控制教育 ;服用纤维素组在饮食控制教育的基础上、每天服用 8g纤维素。实验前及观察 6个月后 ,分别进行口服葡萄糖耐量试验。结果 :每日服 8g纤维素 1个月 ,受试者血清甘油三酯由 (4 .39± 4 .0 9)mmol/L降到 (2 .5 6± 1.91)mmol/L ;血清胆固醇由 (6 .6 3± 0 .6 3)mmol/L降到 (5 .4 9± 1.11)mmol/L。与对照组相比 ,纤维素组口服葡萄糖后 2h血糖略有下降 ,但差别不显著。对照组转归为糖尿病的比例最高 ,达 36 .36 % ,而纤维素组仅为 18.8% ,两组间有显著性差异 (P <0 .0 5 )。结论 :服用纤维素可减少糖耐量减低者转归为糖尿病。

Objective: To observe the regulatory functions of a kind of dietary fiber containing mainlyβ-1,6 glucosan on blood lipid and blood glucose. Methods: Based on related diagnostic standards, select the patients with hyperlipidemia, impaired glucose tolerance from physical examination. The patients with hyperlipidemia took 8 g of dietary fiber without controlling their diet and taking drug to reduce blood lipid. After one month of observation, their blood triglyceride and cholesterol were measured. The patients with impaired glucose tolerance were divided into three groups: the control group was received dietary control education only once; The dietary control group was received dietary control education every two months; Dietary fiber group took 8 g of dietary fiber every day as well as receiving dietary control education. Oral glucose tolerance test was carried out before and six months after the experiment. Results: After taken 8 g of dietary fiber every day for one month, the serum triglyceride of the patients was reduced to 2.56±1.91 from 4.39±4.09( mmol/L)and serum cholesterol was reduced to 5.49±1.11 from 6.63±0.63(mmol/L).Compared to the control group, the blood level after 2 hours of taking oral glucose was reduced in dietary group, but not significantly. There were 36.36% of the patients became diabetes in control group while in dietary fiber group there were only 18.8% of the patients became diabetes after 6 months of the experiment (P<0.05), indicating that β-1,6 glucosan can reduce the percentage of the patients with impaired blood tolerance to become diabetes.