骨髓增生异常综合征49例实验室指标分析

Analysis of Dysmyelopoiesis in 49 Patients with Myelodysplastic Syndrome (MDS)

目的 :观察MDS骨髓细胞形态学病态改变血特点。方法 :对 4 9例MDS的骨髓涂片及血片 ,应用瑞氏—姬姆萨混合染液染色 ,进行骨髓及外周血细胞学分析。结果 :粒、红、巨核三系都有不同程度的病态造血。粒系主要以细胞核浆发育不平衡、内外浆、中性粒细胞核分叶不能或pelger Huet样畸形。红系以双核、花瓣核、碎核及巨幼样变为主。结论 :MDS患者以中老年居多 ,三系均有不同程度的病态改变 。

Objective:To study the morphologic abnormalities and its characters in bone marrow (BM) cells in MDS patients.Methods:Morphologic changes in peripheral blood and BM cells were investigated with Wright-Giemsa staining. Results:Dysmyelopoiesis of various degrees was found in all patients, including dyserythropoiesis, dysgranulomonopoiesis and dysmegakaryocytopoiesis. The dysgranulopoietic features were mainly characterized with nuclear-cytoplasmic dissociation of maturation and hyposegmentation of the nucleus (pseudo-Pelger-Huet anomaly), while erythrocytes exhibited megaloblastoid maturation, nuclear lobulation, flower-like nucleus and karyorrhexis.Conclusion:There are trilineage dysplasia of different degrees in MDS, which chiefly affected middle-and old-aged people and presente with RA subtype most frequently.