摘要
Using subtraction cloning, we identified the human N-Myc Downstream- Regulated Gene-2 (hNDRG2), located at 14q11.2, as a candidate tumor suppressor gene. Semi-quantitative RT-PCR showed that the expression of hNDRG2 in 15 of 27 (56%) human GBM tissues and all 6 human glioblastoma cell lines was significantly lower than that in the normal brain. The expression of hNDRG2 also was evaluated in 60 lung-carcinoma patients. 17 of 26 cases of squamous carcinoma and 4 of 11 cases of small cell lung cancer
