The Steric Effect of trans-(1S,2S)-1-Substituted-2-(N,N-dialkyl-amino)-1-indanol Derivatives as Chiral Ligands in the Catalytic Enantioselective Addition of Diethylzinc to Aldehydes

The Steric Effect of trans-(1S,2S)-1-Substituted-2-(N,N-dialkyl-amino)-1-indanol Derivatives as Chiral Ligands in the Catalytic Enantioselective Addition of Diethylzinc to Aldehydes

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摘要 Optically active trans-(1S,2S)-1-substituted-2-(N,N-dialkylamino)-1-indanol derivatives have been prepared and used in the asymmetric addition of diethylzinc to aldehydes to give sec-alcohol in good yield with up to 93.1% enantiomeric excess. Optically active trans-(1S,2S)-1-substituted-2-(N,N-dialkylamino)-1-indanol derivatives have been prepared and used in the asymmetric addition of diethylzinc to aldehydes to give sec-alcohol in good yield with up to 93.1% enantiomeric excess.

作者 Qian Yong XU Hong Fang YANG Xin Fu PAN Guang Ming ZHU

机构地区 Northwest Institute of Nuclear Technology Department of Chemistry Department of Chemical Engineering

出处《Chinese Chemical Letters》 SCIE CAS CSCD 2002年第11期1029-1032,共4页 中国化学快报(英文版)

关键词 DIETHYLZINC enantioselective alkylation indanol derivative. Diethylzinc enantioselective alkylation indanol derivative.

分类号 O623 [理学—有机化学]

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Chinese Chemical Letters

2002年第11期

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The Steric Effect of trans-(1S,2S)-1-Substituted-2-(N,N-dialkyl-amino)-1-indanol Derivatives as Chiral Ligands in the Catalytic Enantioselective Addition of Diethylzinc to Aldehydes

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