摘要
Objectives:To detect the concentration of serum vascular endothelial growth factor (VEGF) in patients with pregnancy induced hypertension (PIH) as well as to explore the role of VEGF in the pathogenesis of Pffl.Methods: Serum VEGF concentrations in 23 healthy nonpregnant women (normal group) ,30 normal pregnant women (control group) and 37 women with PIH (PIH group) were measured by sandwich enzyme- linked immunoadsorbent assay (ELISA). Results: Serum concentrations of VEGF in control group were significantly higher (149.39 + 27.15ng/L) than those in normal group (11.98 + 3.99ng/L) ( P < 0.001) , peaking in the second trimester of pregnancy (183.84 + 49.02ng/L) and decreasing in the third trimester (118.37 + 34.29ng/L) . Serum VEGF concentrations (64.45 + 24.33ng/L) in PIH group were significantly lower than those in normal late pregnancy women of control group (118.37 + 34.29ng/L) ( P < 0.01) . There was a trend that serum VEGF concentrations in PIH group decreased with the severity of Pffl (P < 0.05) . Conclusion: The serum VEGF concentration in PIH women are significantly decreased, which suggests that VEGF may play an important role in the pathogenic mechanism of PIH.
Objectives:To detect the concentration of serum vascular endothelial growth factor (VEGF) in patients with pregnancy induced hypertension (PIH) as well as to explore the role of VEGF in the pathogenesis of Pffl.Methods: Serum VEGF concentrations in 23 healthy nonpregnant women (normal group) ,30 normal pregnant women (control group) and 37 women with PIH (PIH group) were measured by sandwich enzyme- linked immunoadsorbent assay (ELISA). Results: Serum concentrations of VEGF in control group were significantly higher (149.39 + 27.15ng/L) than those in normal group (11.98 + 3.99ng/L) ( P < 0.001) , peaking in the second trimester of pregnancy (183.84 + 49.02ng/L) and decreasing in the third trimester (118.37 + 34.29ng/L) . Serum VEGF concentrations (64.45 + 24.33ng/L) in PIH group were significantly lower than those in normal late pregnancy women of control group (118.37 + 34.29ng/L) ( P < 0.01) . There was a trend that serum VEGF concentrations in PIH group decreased with the severity of Pffl (P < 0.05) . Conclusion: The serum VEGF concentration in PIH women are significantly decreased, which suggests that VEGF may play an important role in the pathogenic mechanism of PIH.
出处
《现代妇产科进展》
CSCD
2002年第5期398-400,共3页
Progress in Obstetrics and Gynecology
基金
This study was supported by Medical Science Technique Foundation of Guangdong Province (970035)
