染色体不稳定分子机制及其与肿瘤发生研究的新进展

Recent Progress in Molecular Mechanisms of Chromosome Instability and Their Association with Carcinogenesis

绝大多数肿瘤特别是实体瘤细胞常表现为染色体不稳定性。本文从纺锤体检测点、多中心体、细胞周期检测点、DNA双链断裂、异常端粒、甲基化等角度综述了染色体不稳定性产生的可能分子机制,以及其与肿瘤发生的关系。这些研究为肿瘤发生分子机制的研究拓展了新的视野,为肿瘤诊断、治疗、分型、预后提供了新的思路。

The persistent presence of chromosome instability (CIN) has been de monstrated in majority of human cancers, particularly in solid cancers. Recent p rogress in molecular and cellular biology as well as cytogenetic has shed light on the possible molecular mechanisms and their association with carcinogenesis. Chromosome instability may result from various causes, including defects of mito tic spindle checkpoint, centrosome aberration, failure of cell cycle checkpoint, DNA double strand break, telomeres dysfunction, hypomethylation and so on. The researches broaden new insight in molecular mechanisms of carcinogenesis and pro vided new ideas in diagnoses, therapy, classification, and prognosis of cancer.