有机氯农药与乳腺癌发病的环境流行病学研究

Environment-epidemiological study on the pollution of organochlorine pesticides and incidence of breast cancer

为探讨乳腺癌发病与有机氯农药污染的关系,采用分阶段整群随机抽样的方法,按乳腺癌标化发病率高低抽取11个乡镇,再随机抽取行政村、自然村.测定各乡镇大米和土壤样品中有机氯各指标的含量,结合各乡镇的乳腺癌发病资料,进行统计分析.结果表明,各乡镇的乳腺癌标化发病率存在统计学显著性差异;大米中d-HCH、g-HCH、五氯酚钠以及土壤的d-HCH含量在各乡镇间有显著性差异;乳腺癌标化发病率与大米中PP -DDD含量呈负相关,相关系数为-0.609.说明经过近20年的降解过程,DDT的衍生物含量最终以PP -DDD居多,并且乳腺癌标化发病率与大米中PP -DDD含量呈负相关.

To probe into relation between the pollution of organochlorine pesticides and the incidence of breast cancer, it was sampled random in 11 towns with multistage cluster technique according to the standardized incidence level of breast cancer, and also sampled in administrative and natural villages. The contents of each organochlorine index in the rice and soil samples were determined, which were combined with the data of breast cancer incidence of each village and town to perform statistic analysis. The standardized incidence of breast cancer in each village and town was significantly different; and it was also significantly different for the contents of d-HCH, g-HCH and sodium pentachlorophenate in rice and the content of d-HCH in soil. The standardized incidence of breast cancer was correlated inversely with the content of PP -DDD in rice statistically, with the correlation coefficient -0.609. It indicated that PP -DDD takes the first place in the content of derivatives of DDT in the past twenty years of degradation; and there existed negative correlation between the standardized incidence of breast cancer and the standardized incidence of breast cancer content of PP -DDD in rice statistically.