盆底肌电刺激治疗膀胱过度活动症20例分析

Analysis of pelvic floor electrical stimulation and tolterodine in treatment for 20 patients with overactive bladder

目的 观察盆底肌电刺激治疗膀胱过度活动症(overactive bladder,简称OAB)的疗效。方法 将经临床症状及尿动力学检查确诊的OAB 40例随机分为电刺激治疗组(20例)及药物治疗组(20例)。电刺激治疗组采用盆腔生物反馈电刺激治疗仪,通过阴道或直肠电极对患者进行阴道或直肠内8～70mA的电刺激治疗10～20次;药物治疗组给予舍尼亭(酒石酸托特罗定片)每次2mg口服,每天2次,共服2周。通过排尿日记、副作用及满意度调查表评价疗效。结果 电刺激治疗组治愈率60％,总有效率85％;药物治疗组治愈率50％,总有效率80％。两组疗效及满意率经Ridit分析无显著性差异(P>0.05);两组治疗副作用比较均有显著性差异(P<0.05)。结论盆底肌电刺激能有效治疗OAB,长期疗效仍需进一步观察研究。

Objective To observe the efficacy of electrical stimulation in treating overactive bladder. Methods 40 patients with OAB were randomly divided into 2 groups. Electrical stimulation group (n = 20) used an instrument for electrical stimulation through a special vagina or rectum probe transfer current (8～70mA), 20 min·qd for 10～20 times. Medical group (n = 20) received oral tolterodine 2 mg·bid for 2 weeks. Results The total effective rate and cure rate (85% and 60%, 80% and 50%, respectively) had no significance difference between 2 groups (Ridit's analysis: P>0. 05). Patients satisfactory rate was increased more significantly in electrical stimulation group than in medical group (P<0. 05). Side effects were commoner with tolterodine. Conclusion Electrical stimulation is effective and safe for overactive bladder. Further study is necessary to show the long--term efficacy and cost analyses of electrical stimulation.