摘要
华蟾蜍毒素(华蟾素)使离体豚鼠输精管产生剂量依赖性收缩反应,利血平化豚鼠输精管及冷藏输精管对华蟾素反应减弱。给酚妥拉明、维拉帕米后,输精管对华蟾素反应均受抑制,溴苄胺可使反应潜伏期缩短。结果提示华蟾素收缩输精管反应可能与其促进肾上腺素能神经末稍NA释放有关。
Cinobufagin, one of the active principles extracted from toad venom,was studied on the isolated vas deferens of the guinea pig. The preparation was suspended in a bath containing 10 ml Krebs solution. Isometrictension of vas deferens was recorded on polygraph with a force displacement transducer. Cinobufagin caused a long- lasting contraction of the vas deferens of the guinea pig-at concentrations of 15 ～50 μmol/L. The contraction was inhibited following reserpini-zation and cold storage treatment.The cinobufagin induced contraction was partlyblocked by pretreatment with phentolamine and verapamil. These results suggest that the cinobufagin induced contraction of vas deferens mightbe related to an action which promotes release of NA from the adrenergic nerve terminals.
出处
《药学学报》
CAS
CSCD
北大核心
1992年第4期252-255,共4页
Acta Pharmaceutica Sinica
