摘要
药物灭螺是血吸虫病防治的重要环节之一,为了寻找更好的灭螺增效剂,设计合成了O,O′-二烷基-O″-(2-取代-3-苯并呋喃乙腈-α-肟)磷酸酯和硫代磷酸酯(Ⅵ_(1～13)),O,O′-二烷基-O″-(2-噻吩乙腈-α-肟)磷酸酯(Ⅹ_(14,15))等化合物15个。初步试验表明,化合物X_(15)与五氯酚钠合用有较强灭螺增效作用,化合物Ⅹ_(14)及Ⅵ_(1,2,3,6,8,10,12,13)亦有一定的灭螺增效活性,化合物Ⅵ_(10,12)除增效作用外本身尚有一定的杀螺活性。
Chemical molluscicides are useful in schistosomiasis control. A synergistcan potentiate the efficacy and reduce the dosage of a molluscicide, thus decreasing thetoxicity and environmental pollution. In order to search for potential molluscicidalsynergists, 13 compounds of O, O - dialkyl- O - (2-substituted- 3-benzofurylacetonitrile-α-oximino)phosphate or thiophosphate (VI_(1 ～13)) and 2 compounds of O, O - dialkyl-O-(2-thienylacetonitrile-α-oximino)phosphate(X_(14.15))were prepared. Preliminary testdemonstrated that compound X_(15) had strong synergic effect with sodium pentachlorophenolin combating mollusks. Compounds X_(14) and VI_(1.2.3.6.8.10.12. 13.) also showed some molluscicidalsynergistic activity.
出处
《药学学报》
CAS
CSCD
北大核心
1992年第4期261-267,共7页
Acta Pharmaceutica Sinica
关键词
灭螺增效剂
磷酸酯
molluscacidal synergist
O,O'--dialkyl--O''--(2--substituted--3--benzo--furylacetonitrile--α--oximindno)phosphate
O, O'--Dialkyl--O''--(2--thienylacetonitrile--α--oximino)phosphate
