山莨菪碱及阿托品对大鼠肝、横纹肌及趾蹠血管的作用

EFFECTS OF ANISODAMINE AND ATROPINE ON THE MICROVASCULATURE OF LIVER,SKELETAL MUSCLE AND FOOT-PAD SKIN IN ANESTHETIZED RATS

阿托品类药物对感染性休克等病有突出疗效,作用机理较复杂,主要是直接促进微循环的作用。以前我们报告了这类药物扩张大鼠皮肤血管的高度活性。本文报告对调节微循环血量有重要作用的肝脏、横纹肌及皮肤(趾跖)对阿托品类药物的同时收缩和扩张两种不同性质的反应。

Rats were urethanised and kept in a constant temperature chamber.The surface temperature of various organs including the liver and the armpit skeletal mus-cle were monitored with a special mercury thermometer through a narrow hole on the skincut with scalpel. The temperature of the foot- pad skin were measured using a thermome-ter as reported previously. After iv of anisodamine or atropine at doses of 12. 5 ～50μg/kg the temper-ature of the liver and the armpit skeletal muscle were significantly reduced in adose-dependent manner but the skin temperature was increased. Temperature changeswere observed 5 min after drug administration, reaching peak height at about 15 min andmaintained for one hour or so. Isoprenaline, dopamine and aminophylline iv showed only a tempera-ture-elevating effect, while serotonin and noradrenaline caused only a tempera-ture- decreasing effect in all the three organs mentioned above. Although the functional significance of the opposite effects on the microcirculation ofdifferent tissues remain to be defined, the effects of atropine- like drugs must result in aredistribution of circulating blood and may have beneficial effects on the survival of somevital organs such as brain, lungs, kidneys…especially in shock.