大狼毒三萜类化学成分的研究

TRITERPENE CONSTITUENTS FROM EUPHORBIA NEMTOCYPHA HAND-MAZZ

自大戟科(Euphorbiaceae)植物大狼毒(Euphorbia nematocypha Hand—Mazz)根的乙醇提取物的苯溶解部分,经20％AgNO_3硅胶层析,分离得到七个三萜类成分。根据光谱(IR,EIMS,~1H—NMR和^(13)C—NMR)和化学方法,确定其中一个化合物为新化合物,命名为大狼毒醇(nematocyphol,Ⅳa),其它化合物为已知物:印度荆芥醇乙酸酯(nepehinol acetate Ⅰ),日尔曼醇乙酸酯(germanicol acetate Ⅱ),大戟醇(euphol,Ⅲ),蒲公英醇(taraxasterol,Ⅴa),24-亚甲基环阿尔廷醇(24-methylenecycloartanol,Ⅴa)和印度荆芥醇(nepehinol,Ⅶa)。这些化合物均为首次从大狼毒中得到。

Seven triterpenoids have bo isolated from the roots of Euphorbia nema-tocypha Hand-Mazz. through chromatography on 20% AgNO_3-silica gel. One of themwas identified as a new compound named nematocyphol on the basis of spectral data(IR, EIMS, 1~H-NMR and (13)~C-NMR). Its structure was deduced as IVa. Other com-pounds were identified as nepehinol acetate (Ⅰ), germanicol acetate (Ⅱ), euphol (Ⅲ),tanaxastanol (Ⅴa), 24-methylenecycloartanol (Ⅵa)and nepehinol (Ⅶa). These com-pounds were obtained for the first time from this plant.