摘要
4-羟基联苯双酯(Ⅱ)为联苯双酯(Ⅰ)的代谢产物。本文报道了2-溴-3,4-亚甲二氧基-5-苄氧基苯甲酸甲酯(6)的合成探讨,并将6与2-溴-3,4-亚甲二氧基-5-甲氧基苯甲酸甲酯(8)进行不对称的Ullmann缩合反应,再氢解制得化合物Ⅱ。
This paper reports the synthesis of dimethyl 4-hydroxy-4′ -methoxy-5,6,5′, 6′-bis-methylenedioxybiphenyl-2,2′-dicarboxylate (Ⅱ). Various conditions for bromination were tried to findthe best one for synthesis of the key intermediate compound 6. After Ullmann condensation of 6 with8 and hydrogenolysis,the title compound Ⅱ was obtained. It was proved to be identical with the isolat-ed metabolite of biphenyl diester by spectral data.
出处
《药学学报》
CAS
CSCD
北大核心
1992年第8期582-588,共7页
Acta Pharmaceutica Sinica
关键词
联苯双酯
芳香溴化反应
氢解
Dimethyl 4--hydroxy--4'--methoxy--5, 6, 5' 6'--bismethylenedioxybiphenyl--2, 2'--dicarboxylate
Aromatic bromination
Unsymmetric Ullmann condensation
Hydrogenolysis
