摘要
三七中人参三醇甙(简称PTS)能明显对抗大鼠结扎冠状动脉诱发的缺血性心律失常及再灌注性心律失常,并可使缺血再灌注引起的心肌梗塞范围明显缩小。对iv CaCl_2-Ach引起的小鼠房颤或房扑也有明显的保护作用。PTS还可明显延长小鼠在常压缺氧条件下的存活时间。
PTS, one of the major effective components of Panax notoginseng was found to exertremarked antiarrhythmic activities on coronary artery ligation induced ischemic and reperfused arry-thmias in rats. PTS also reduced the size of myocardial infarct. For iv CaCl_2-Ach induced atrial fibr-illation and/or flutter in mice, PTS produced a significant protective effect. In addition, PTS showedan action of prolonging the life under the condition of normobaric hypoxia.
出处
《药学学报》
CAS
CSCD
北大核心
1992年第9期641-644,共4页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助课题 3880739
关键词
三七
人参三醇甙
心律失常
Panaxatriol saponins
Panax notoginseng
Myocardial ischemia
Arrhythmias
