摘要
血管紧张素转化酶抑制剂(ACEI)是近年发展的一类新型抗高血压和治疗心力衰竭的有效药物。有关研究工作还在世界范围内广泛进行。 本研究组前曾报道一类具有降压活性的N-取代甘氨酸的合成。作者等根据Cushman等的血管紧张素转化酶(ACE)与底物的作用模型和构效关系。
Nine N-(4-substituted amino-4-oxobutyryl) N-substituted glycines expected tohave inhibitory activity on angiotensin-converting enzyme were synthesized. All of the title com-pounds and their t-butyl esters were unreported in the literature. In preliminary test in rats, com-pounds V_2,V_6 and V_7 showed marked hypotensive activity.
出处
《药学学报》
CAS
CSCD
北大核心
1992年第9期717-720,共4页
Acta Pharmaceutica Sinica
基金
国家自然科学基金
关键词
ACEI
降压药
N-(4-Substituted amino-4-oxobutyryl)-N-substituted glycine
t-Butyl ester of N-substituted glycine
N-Substituted succinamic acid
Angiotensin-converting enzyme inhibitor(ACEI)
