摘要
在相对湿度小于临界相对湿度的条件下,在温度为60~90℃、相对湿度为60~80%范围内测定了维生素C片剂的色泽(以相对反射率R表示)变化速率,含量C变化速率及片剂溶液的色泽(以透光率T表示)变化速率。三者的表观速率常数k与热力学温度T和相对湿度RH的关系通式为k=k’exp(-E/RT)exp(mRH),k’和m为常数,E为表观活化能。不同速率常数的k’,m和E值均不同。
Under the condition of relative humidity less than the critical relative humidity,the discoloration rate and decomposition rate of vitamin C tablet and the discoloration rate of vitamin Ctablet in solution were studied at temperatures 60~90°C and relative humidities 60%~80%. Thegeneral equation of the relationship between the apparent rate constant k, absolute temperature T andrelative humidity RH is: k=k′exp(-E/RT) exp(mRH) ,where k′and m are constants,E is apparentactivation energy. The values of k′, m and E for discoloration, decomposition and discoloration insolution are different.
出处
《药学学报》
CAS
CSCD
北大核心
1992年第9期705-710,共6页
Acta Pharmaceutica Sinica
基金
国家自然科学基金
关键词
维生素C
分解动力学
片剂
Vitamin C tablet
Discoloration kinetics
Decomposition kinetics