新型缩氨基硫脲衍生物——氨基巯三唑Schiff碱的合成与抗菌活性

SYNTHESIS AND BACTERIOSTATIC ACTIVITY OF NEW THIOSEMICARBAZONE DERIVATIVES-AMINO MERCAPTOTRIAZOLE SCHIFF BASES

设计合成了新型缩氨基硫脲衍生物4-氨基-3-(呋喃-2)-5-巯基-1,2,4-三唑及其十种不同醛的Schiff碱衍生物,并进行了抑菌实验。结果表明:Schiff碱化合物结构中的甲亚胺基是该类化合物的活性功能基。苯环上更换不同的取代基对其活性有一定的影响,其中化合物4-(5-硝基亚糠基氨基)-3-(呋喃-2)-5-巯基-1,2,4-三唑(Ik)抗菌活性最高且抗菌谱最广;化合物4-亚水杨基氨基-3-(呋喃-2)-5-巯基-1,2,4-三唑(Ib)具有较强的抑霉活性。

4-amino-3-(furan-2)-5-mercapto-1,2, 4-triazole (Ia) and its ten Schiff basesderived from Ia with different aldehydes were synthesized. All the compounds were screened for activi-ty against seven bacteria and three fungi. Most compounds were found to possess different inhibitioneffect on some bacteria and fungi. The azomethine group of Schiff bases is the active functional groupand the substituted groups on the phenyl ring had definite effect on the bacteriostatic and fungistaticactivities. 4- (5-Nitrofurfurylideneamino) -3- (furan-2) -5- mercapto-1,2, 4-triazole (Ik) showed themost powerful antibacterial activity and broad antibacterial spectrum, while 4-salicylideneamino-3-(fu-ran-2)-5-mercapto-1,2,4-triazole possessed strong activity against fungi.