红花黄素对高血压大鼠的降压作用及对肾素-血管紧张素的影响

HYPOTENSIVE EFFECTS OF SAFFLOWER YELLOW IN SPONTANEOUSLY HYPERTENSIVE RATS AND INFLUENCE ON PLASMA RENIN ACTIVITY AND ANGIOTENSIN II LEVEL

红花(Carthamus tinctorius L)为菊科植物,是活血化瘀的传统中药。红花黄素(saffloweryellow,SY)是从红花中提取的查耳酮类化合物。据黄正良等报道,iv SY对麻醉犬与家兔有急性降压作用,并有抗凝血、抗缺氧等作用。本室研究证明SY能抑制免疫功能。本文探讨SY对自发性高血压大鼠(spontaneously hypertensive rat,SHR)的降压作用及与肾素-血管紧张素的关系,以探讨ig SY用于抗高血病的可能性。

Safflower yellow (SY) is a mixture of chalconoid compounds extracted fromCarthamus tinctorius L. Ig SY 1～2 g·kg^(-1)·d^(-1)lowered the blood pressure of spontaneously hypertensiverats (SHR), for about 1.86～3.86 kPa. Five weeks after administration of SY, the plasma renin ac-tivity and angiotensin Ⅱ level diminished in the SHR experimental groups. These suggest that the de-crease of blood pressure is mediated by the renin-angiotensin system.