比索洛尔治疗慢性心力衰竭的临床分析

The Clinical Effect of Treatment with Bisoprolol in Chronic Heart Failure

目的:观察比索洛尔治疗慢性心力衰竭(CHF)的临床疗效。方法:68例CHF患者随机分为比索洛尔组44例和常规治疗组24例,常规组应用传统心力衰竭治疗(血管紧张素转换酶抑制剂、利尿剂、洋地黄制剂)、比索洛尔组在传统治疗的基础上加用比索洛尔。两组治疗半年,观察药物的疗效。结果:治疗后比索洛尔组较常规治疗组心功能明显改善、明显减慢心率、降低血压;左室射血分数明显增加[(49.99±9.89)％vs(39.35±7.56)％];左室舒张末径、收缩末径明显缩小[(57.56±8.22)mm vs(63.47±8.55)mm;(44.57±9.21)mm vs(51.65±9.21)mm]。结论:在常规治疗CHF基础上加用比索洛尔可明显增加疗效,显著提高心功能,明显缩小左心室舒张及收缩末径。

Objective: To evaluate the clinical effect of bisoprolol on patients with chronic heart failure (CHF) .Methods: 68 patients with) CHF were randomly divided into two groups. ACEI+digoxin+diuretic were given to the 24 patients in the group control. The patients in the group bisoprolol were treated with bisoprolol+ACEI+digoxin+diuretic. All the patients were followed up for 1/2 year. clinical effect of bisoprolol, LVEDD, LVESD and LVEF were observed. Results; The cardiac function in the group bisoprolol was improved significantly (P<0.05) compared with the patients in the group control; LVEF of the patients in the group bisoprolol were increased significantly[(49.99±9.89)%vs(39.35±7.56)%, (P<0.05) compared with the patients in the group control, the LVEDD and LVESD of the patients in the group bisoprolol were significantly decreased[(57.56±8.22)mm vs(63.47±8.55)mm, (P <0.05);(44.57±9.21)mm vs(51.65±9.21)mm,(P<0.05) . Conclusion: Risoprolol could improve the cardiac function of the patients with CHF with the standard treatment. The exercise endurance of theses patients were increased at the same time.