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阿托伐他汀与氯吡格雷相互作用的争议及评价 被引量：7

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摘要 冠心病(急性冠脉综合征)是以动脉粥样硬化和血栓形成为基础的疾病.临床预防和治疗中,抗动脉粥样硬化和抗血栓治疗是两项基本的而且是最重要的治疗措施.
作者 赵水平 张大庆
机构地区 中南大学湘雅二医院心内科
出处 《中国医药导刊》 2004年第1期56-58,共3页 Chinese Journal of Medicinal Guide
关键词 阿托伐他汀 氯吡格雷 药物相互作用 抗血小板药物 抗动脉粥样硬化 抗血栓治疗
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献20

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同被引文献96

  • 1Eric L Eisenstein, DBA,Kevin J. Anstrom, PhD,David F. Kong, MD,Linda K. Shaw, MS,Robert H. Tuttle, MSPH,Daniel B. Mark, MD, MPH,Judith M. Kramer, MD, MS,Robert A. Harrington, MD,David B. Matchar, MD,David E. Kandzari, MD 1,Eric D. Peterson, MD, MPH,Kevin A. Schulman, MD,Robert M. Califf, MD,李呈亿（译）,David E. Kandzari, MD.氯吡格雷的使用与药物洗脱支架植入后远期临床结果[J].美国医学会杂志（中文版）,2007,26(3):131-139. 被引量：59
  • 2Briguori C, Visconti G, Focaccio A,et al. Novel approaches for pre- venting or limiting events(Naples) Ⅱ trial impact of a single high loading dose of atorvastatin on periproeedural myocardial infarction [J]. J Am Coll Cardiol,2009,54(23) :2157- 2163.
  • 3Williams D, Feely J. Pharmacokinetic- pharmacodynamic drug in- teractions with HMG - CoA reductase inhibitors[J]. Clin Pharma- cokinet,2002,41(5) :343 - 370.
  • 4Clarke TA,Waskell LA. The metabolism of clopidogrel is catalyzed by human cytochrome P450 3A and is inhibited by atorvastatin [J]. Drug Metab Dispos,2003,31(1) :53 - 59.
  • 5Lau WC,Waskell LA, Watkins PB, et al. Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: A new drug - drug interaction[J]. Circulation, 2003,107(1) : 32 - 37.
  • 6Saw J, Steinhubl SR, Berger PB. Lack of adverse clopidogrel - at- rorvastatin clinical interaction from secondary analysis of a ran- domized, placebo - controlled clopidogrei trial [J]. Circulation, 2003,108(8) : 921 - 924.
  • 7Gorchakova O, yon Beckerath N, Gawaz M. Antiplatelet effects of a 600 mg loading dose of clopidogrel are not attenuated in patients receiving atorvastatin or simvastatin for at least 4 weeks prior to coronary artery stenting[J]. Eur heart J,2004,25(21): 1989 - 1902.
  • 8Savi P,Pereillo JM, Uzabiaga MF,et al. Identification and biologi cal activity of tb.e active metabolite of clopidogrel[J]. Thromb Hae most,2000,84(5) :891 - 896.
  • 9Laufs U,Gertz K,Huang P,etal. Atorvastatin upregulates type nitric oxide synthase in thrombocytes, decreases platelet activa- tion,and protects from cerebral ischemia in normocholesterolemic mice[J]. Stroke,2000,31(10):2442 - 2449.
  • 10Frere C, Cuisset T, Morange PE, et al. Effect of cytochrome p450 polymorphisms on platelet reactivity after treatment with clopidogrel in acute coronarysyndrome [J]. Am J Cardiol, 2008, 101: 1088-1093.

引证文献7

二级引证文献79

中国医药导刊
2004年 第1期

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