急性柯萨奇病毒性心肌炎与氧化应激

Acute Coxsackie Virus Myocarditis and Oxidative Stress

目的 探讨急性柯萨奇病毒性心肌炎 (ACM)患者体内的氧化应激。方法 采用分光光度分析法检测 50例ACM患者和 50例健康志愿者 (对照组 )的血浆谷胱甘肽_S_转移酶 (GST)和过氧化脂质 (LPO)值及红细胞谷胱甘肽过氧化物酶 (GPX)和过氧化脂质 (LPO)值。结果 与对照组比较 ,ACM患者组的血浆LPO和红细胞LPO平均值显著升高 (P <0 0 1～ 0 0 0 1) ,而血浆GST和红细胞GPX平均值显著降低 (P <0 0 0 1) ;ACM患者随着GST值的降低 ,血浆LPO和红细胞LPO值逐渐升高 (P <0 0 1～ 0 0 0 1) ,而红细胞GPX值逐渐降低 (P <0 0 0 1) ;ACM患者遭受潜在氧化损伤的危险度至少是对照组的 2 2倍 ,而最大可达 139 8倍。结论 ACM患者体内一系列自由基连锁反应加剧 。

ObjectiveTo study oxidative stress in acute coxsac kie virus myocarditis (ACM) patients. Methods50 ACM paient s and 50 healthy volunteers (HV) were enrolled in a randomized study. The values of glutathione_S_transferase (GST) and lipoperoxide (LPO) in plasma as well as those of glutathione peroxidase (GPX) a nd LPO in erythrocytes were determined with spectrophotometric assays. ResultsC ompared with HV group, the average values of LPO in plasma and erythrocytes in A CM group were significantly increased ( P <0 001), while those of GST in plas ma an d GPX in erythrocytes in ACM group were significantly decreased ( P <0 001). With decreased GST value in ACM patients, the values of LPO in plasma and erythrocyte s were increased gradually ( P <0 001), while the value of GPX was decreased gradu ally ( P <0 001). The risk of potential oxidative damage in ACM patients was at le ast 2 2 times as large as HV group. ConclusionsThe fi ndings in this study sugge sted that a series of free radical chain reactions in ACM patients severely aggr avated and induced severe oxidative stress and potential oxidative damage in the ir bodies.