高危性妊娠期肝内胆汁瘀积症产前预测

The predictive indexes for high disk intrahepatic cholestasis of pregancy

目的 探讨高危性妊娠期肝内胆汁淤积症 (ICP)产前预测指标。方法 对 15 6例ICP患者多项临床指标进行观察 ,并将其与围产儿结局进行对照分析。结果 皮肤瘙痒持续时间≥ 3周 ,血清转氨酶和胆红素同时升高 ,胆酸 10倍以上升高者发生高危性ICP的机会明显高于皮肤瘙痒时间≤ 3周 (P <0 .0 1) ,单纯转氨酶升高而胆红素正常 (P<0 .0 1)和胆汁酸增高 <10倍 (P <0 .0 5 )。结论 皮肤瘙痒时间≥ 3周 ,血清转氨酶和胆红素同时升高以及胆酸增高在正常

Objective To investigate the clinical predictive indexes for high risk intrahepatic cholestasis of pregnancy (ICP).Methods Multiple clinical indexes were observed in 156 patients with ICP, and the neonatal outcomes were compared with these indexes.Results The incidence of high risk ICP were higher in patient with pruritic period persisting over three weeks or elevated level of both serum concentration of transaminase bilirubin over than ten times normal serum cholyglycine than those with pruritic period less than three weeks ( P <0.01),abnormal serum concentration of transaminase only and less than ten times normal serum cholyglycine ( P <0.05).Conclusion They might be the predictive indexes for high risk ICP that the itching period lasting more than three weeks, both serum concentration of transaminase and bilirubin rising abnormally and over than ten times normal serum cholyglycine.