高血压与胰岛素抵抗、血管紧张素Ⅱ及肿瘤坏死因子α关系的研究

A study of correlation between insulin resistance,angiotensin Ⅱ,tumor necrosis factor α and hypertension

目的 探讨高血压与胰岛素抵抗、血管紧张素Ⅱ及肿瘤坏死因子α的关系。方法 高血压组 70例 (男42例 ,女 2 8例 ,平均年龄 63 .6岁 ) ,正常对照组 2 4例 (男 15例 ,女 9例 ,平均年龄 64 .7岁 )。全部受试者空腹 12小时 ,于次日清晨采集静脉血 ,检测血糖、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、胰岛素、血管紧张素Ⅱ及肿瘤坏死因子α。用HOMA -IR法评估胰岛素抵抗指数。进行多因素Logistic逐步回归分析 ,筛选出相关的危险因素。 结果 高血压组与对照组比较 ,血糖、甘油三酯、胰岛素和肿瘤坏死因子α增高 ,差异有显著性 (P <0 .0 5 ) ;胰岛素抵抗指数、血管紧张素Ⅱ明显增高 ,差异有非常显著性 (P <0 .0 1)。多因素Logistic逐步回归分析显示 ,高血压与血管紧张素Ⅱ、肿瘤坏死因子α和胰岛素抵抗指数呈独立正相关。结论 高血压患者存在胰岛素抵抗。胰岛素抵抗指数。

Objective To investigate the relationship between insulin resistance,angiotensin Ⅱ,tumor necrosis factor α and essential hypertension .Methods 24 normotensives and 70 patient with hypertension were recruited in this study.The fasting serum sugar,total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),insulin,angiotensin Ⅱ(AT-Ⅱ),tumor necrosis factor α (TNFα) were detected respectively.Insulin resistance index(IRI)was evaluated with HOMA-IR method.Results There were obviously higher level of blood sugar,triglyceride,Insulin and TNFα in hypertensive group than those in control group( P <0.05).AT-Ⅱ and IRI were significantly higher in hypertensive group than those in control group( P <0.01).Logistic regression analysis revealed that AT-Ⅱ,TNFα and IRI were positively correlation with hypertension .Conclusion IRI,AT-Ⅱ and TNFα are independent risk factors for hypertension.