摘要
内毒素是革兰氏阴性菌的主要毒性成分,可引发机体的炎症级联反应,被公认为是导致全身炎症反应综合,征、脓毒症、严重休克、多脏器功能衰竭的主要致病因子。深入研究内毒素的受体和信号转导可望为脓毒症等危重病人的治疗提供新思路。
出处
《国外医学（麻醉学与复苏分册）》
2004年第1期1-4,共4页
Foreign Medical Sciences(Anesthesilolgy and Resuscitation)
参考文献18
-
1Angus DC, Linde-Zwirble WT, Lidieker J, et al. Epidemiology of severe sepals in the United States: analysis of incidence,outcome, and associated costs of care. Crit Care Meal,2001,29(7) : 1303-1310.
-
2Gegner JA, Uleviteh RJ, Tobias PS. Lipopolysaccharide (LPS) signal transduction and clearance. Dual roles for LPS binding protein and membrane CD14. J Biol Chem,1995,270:5320-5325.
-
3Haziot A, Ferrero E, Kontgen F, et al. Resistance to endotoxin shock and reduced dissemination of Gram-negative bacteria in CD14-deficient mice. Immunity, 1996,4:407-414.
-
4Myc A, Buck J, Gonin J, el al. The level of lipopolysaccharide-binding protein is significantly increased in plasma in patients with the systemic inflammatory response syndrome. Clin Diagn Lab Immunol, 1997,4(2) : 113- 116.
-
5Verbon A, Dekkers PE, ten Hove T, et al. IC14, an anti-CD14 antibody, inhibits endotocin-mediated sysptoms and inflammatory responses in humans. J Immunol,2001, 166:3599-3608.
-
6Pohorak A, He X, Smimova I, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Th4 goae. Science, 1998, 282: 2085-2088.
-
7Hoshino K, Takeuchi O, Kawai T, et al. Cutting edge: toll-like receptor 4 (TLR4) deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the LPS gene product. J Immunol, 1999, 162:3749-3752.
-
8Arbour NC, Lorenz E, Schutte BC, et al. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet, 2000, 25 (2) : 187-191.
-
9Agnese DM, Calvano jE, Hahm SJ, et al. Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections. J Infect Dis, 2002,186(10):1522-1525.
-
10Lorenz E, Mira JP, Frees KL, et al. Relevance of mutations in the receptor in patients with gram-negative septic shock. Arch intern Med, 2002,162(9) : 1028-1032.
同被引文献7
-
1Medzhitov R,Preston-Hudburt P,Janeway CA.A human homologne of the Drosophih Toll protein signals activation of adaptive immunity.Nature,1997,388(6640):394-397.
-
2Garg PK,Khanna S,Bohidar NP,et al.Incidence,spectrum and antibiotic sensitivity pattern of bacterial infections among patients.J Gastrpenterol Hepatol,2001,16(19):1055-1059.
-
3Schwandner R,Dziarski R,Wesche H,et al.Peptidoglycan-and lipoteiehoic acid-induced cell activation is mediated by toll-like receptor2.J Biol Chem,1999,274,17406-17409.
-
4Chcw JC,Young DW,Golenbock DT,et al.Toll-like receptor 4 mediates lipopolysaccharide-induced signal transduction.J Biol Chem,1999,274:10689-10692.
-
5Kieehl S,Lorenz E,Beindl M,et al.Toll-like receptor 4 polymorphism and atherogenesis.N Engl J Med,2002,347:185-192.
-
6中华医学会消化病学分会胰腺疾病学组.中国急性胰腺炎诊治指南(草案)[J].中华消化杂志,2004,24(3):190-192. 被引量：1765
-
7高宏凯,周总光,李园,王存.人胰腺组织Toll样受体4表达的研究[J].华西医学,2004,19(2):241-242. 被引量：3
二级引证文献2
-
1陈文亮,武世荣,段俊芳,赵小龙,郭波,李文龙,贾彬,苏继荣.两种类型急性胰腺炎患者早期外周血Toll样受体4基因多态性分析[J].中华临床医师杂志（电子版）,2017,11(24):2480-2485.
-
2马云鹤,席红卫,游志恒.Toll样受体4与急腹症[J].中华临床医师杂志（电子版）,2017,11(6). 被引量：1
-
1宋艳,丁国华,桂元,黄金平.黄芪多糖对肾盂肾炎大鼠肾脏TLR4表达的影响[J].武汉大学学报（医学版）,2006,27(5):605-608. 被引量：12
-
2李薇,谢闻悦,张卫云,张璇,张玉新,高贵阳.HLA-DR/CD14在外周血单核细胞中的表达及其临床意义[J].解放军医学杂志,2011,36(1):61-63. 被引量：18
-
3许晓光,王铁军,李宏.45例烧伤死亡原因分析[J].黑龙江医药科学,1995,0(2):74-75.
-
4朱音,高丽君,曾和英.严重肝损伤病人的急救护理[J].护理学杂志（综合版）,2002,17(10):747-748. 被引量：2
-
5景少博,魏晋山,王栋.严重多发伤128例救治分析[J].中国卫生产业,2011,8(12X):63-64.
-
6赵学维,孙耀昌,徐志飞,答作为.机械通气治疗创伤性连枷胸（附10例报告）[J].中华创伤杂志,1996,12(6):380-382. 被引量：18
-
7高卫卫,李会利.亚低温治疗脑损伤30例护理体会[J].山东医药,2005,45(23):88-88.
-
8李华斌,张谢夫,李华英.严重肝破裂手术治疗的体会:附34例分析[J].中国普通外科杂志,2005,14(2):152-153. 被引量：11
-
9史有松.剧烈运动引起严重休克并发多脏器损伤抢救成功1例报告[J].蚌埠医药,1994,12(1). 被引量：1
-
10李红云,姚咏明,盛志勇.Toll样受体与脓毒症的研究进展[J].中华烧伤杂志,2002,18(5):314-317. 被引量：19
