不同分子链段的魔芋葡甘露聚糖对实验性糖尿病小鼠血糖含量的影响

Studies on the Antidiabetic Effect of Konjac Glucomannan with Different Molecular Chains on Experimental Diabetes Mice

以四氧嘧啶诱导糖尿病小鼠为实验模型 ,研究了不同分子链段的魔芋葡甘露聚糖KGM Ⅰ ,KGM Ⅱ ,KGM Ⅲ和魔芋精粉的降血糖效果。结果显示 ,当灌胃剂量为 1 5 g/kg时 ,小鼠血糖下降率分别为 5 5 37% ,80 6 0 % ,33 4 4 %和 4 0 9% ,以KGM Ⅱ的降糖效果最好。研究还显示KGM Ⅰ、KGM Ⅱ和魔芋精粉均可增强正常小鼠腹腔巨噬细胞的吞噬功能和由DNFB所致的迟发性变态反应 ,且KGM Ⅱ的效果显著强于KGM Ⅰ和魔芋精粉。

The antidiabetic effect of konjac glucomannan with different molecular chains on experimental diabetes mice was studied.The result showed that KGM-Ⅰ,KGM-Ⅱ,KGM-Ⅲ and konjac flour can lower blood sugar of alloxan-induced hyperglycemic mice.When the dose was 1.5 g/kg,the decrease rates of blood sugar was 55.37%,80.60%,33.44% and 40.9%, respectively.It also showed that KGM-Ⅱ (Po,0.2 g/kg.d×7d) can significantly intensify DTH induced by DNFB and improve phagocytosing function of peritoneal macrophage (PM Φ) separetely.