247例小儿败血症病原学分析

Pathogen analysis of 247 cases of septicemia

目的:分析小儿败血症细菌种类的变迁和对抗生素耐药性的改变。方法:回顾分析近20年来247例小儿败血症的病原学及抗生素敏感性试验。结果:细菌培养的阳性率有所降低;金黄色葡萄球菌引起的败血症明显减少,凝固酶阴性的葡萄球菌和革兰氏阴性杆菌引起的败血症明显增多,各占1/3左右;细菌对青霉素、氨苄青霉素的耐药性明显上升,在80%以上,对利福平敏感性很高,达90%。除发现一例微球菌对万古霉素耐药外,其余细菌均对万古霉素敏感。结论:随着年代变化,败血症的常见致病菌发生改变,对多种常用抗生素耐药性增加,临床经验性治疗时应充分考虑到这一点。

Objective To analyse the vicissitudes of the pathogen and the drug resistance of bacteria in children. Methods Retrospectively,to analyze the pathogen and sensitivity to antibiotics by studying 247 cases of septicemia. Results 247 cases have positive blood culture result. There has been a fall in the positive rate of blood culture. The major pathogens are coagulase-negative staphylococcus (CONS) and Gram-negative bacillus which are about two-third. Some bacteria have produced high resistance to common clinic antibiotics such as penicillin and ampicillin . But they have high sensitivity to vancomycin and rifampicin. Conclusion As the years passed by, the familiar pathogen of septicemia has changed. Resistance of the isolated pathogens to several commonly used antibiotics should be considered.