29例赖特综合征临床分析

Clinical Analysis of Twenty-nine Cases with Reiter's Syndrome

【目的】了解赖特综合征 (RS)在我国发病的临床特点。【方法】分析 2 9例RS患者年龄、性别、发病年代情况和临床表现 ,分析RS患者眼炎、骶髂关节炎与HLA B2 7的关系 ,以及以性病型和肠病型发病为特点的患者与HLA B2 7的关系。【结果】发病年龄以 18～ 4 0岁为多 ,共 2 0例 (6 9.0 % ) ;男性 2 5例 (86 .2 % ) ;伴发热者 2 5例 (86 .2 % ) ;关节炎中以膝关节最易受累 ,2 3例 (79.3% ) ;2 9例患者中 ,有 2 7例检查了HLA B2 7,其中 2 2例阳性 ,占受检患者的 (81.5 % ) ,HLA B2 7与病情无关。【结论】2 0～ 4 0岁为好发年龄 ;男性患病数明显多于女性 ;近 2 0年患病率呈上升趋势 ;临床表现多有发热 ;外周关节以膝关节最易受累。

To understand the clinical features of Reiter's Syndrome (RS) occurred in our country.The ages, sexes,the condition of attack period and clinical manifestations in 29 patients with RS were analyzed. Their clinical features were summarized and analyzed, exploring whether ophthalmia, sacroiliitis , sexual and intestinal subsets of RS were related to human leukocyte antigen (HLA)- B27 molecules. The common ages of disease onset were 18 to 40 years old, a total of 20 cases (69.0%). Twenty-five cases were male ( 86.2%), 25 cases were accompanied with fever (86.2%) and the knee joints were most susceptibly involved in arthritis, a total of 23 cases (79.3%). HLA-B27 molecules were examined in 27 out of 29 cases, showing positive in 22 cases (81.5%). No relation of HLA- B27 to disease severity was found. [Conclusion] RS usually occurs at the age of 18～40 years old, males are more susceptible than females. Its morbidity is ascending in recent 20 years. Fever is a common clinical manifestation, and knees are mostly involved in peripheral joints.