5-Fu联合CF和L-OHP2种给药方案治疗晚期大肠癌的临床研究

Continuous Infusion of Fluorouracl with Oxaliplatin and Calcium Leucovorin in the Treatment of Patient with Advanced Colorectal Carcinoma

目的 探讨持续静脉滴注氟脲嘧啶 ( 5 Fu)联合奥沙利铂 (L OHP)、亚叶酸钙 (CF)治疗晚期大肠癌的临床疗效和不良反应。方法 对 43例大肠癌患者行持续静脉滴注 5 Fu 2 5 0mg/m2 ,第 1～ 10天 ;CF 10 0mg静脉滴注 ,第 1～ 10天 ;L OHP 13 0mg/m2 静脉滴注 2h。对 3 2例大肠癌患者行常规静脉滴注 5 Fu 5 0 0mg/m2 ,第 1～ 5天 ;CF 2 0 0mg静脉滴注 ,第 1～ 5天 ;L OHP13 0mg/m2 静脉滴注 2h。对 2组临床疗效进行对比观察。结果 持续静脉滴注组有效率为 48.8% ( 2 1/ 43 ) ,常规静脉滴注组有效率为 2 5 .0 % ( 8/ 3 2 ) ,2组疗效比较有显著性差异。常规静脉滴注组不良反应发生率较持续静脉滴注组高 ,主要为骨髓抑制、恶心呕吐等。结论 5

Objective To study the treatment effect and the side effect of continuous infusion of fluorouracl with oxaliplatin and calcium leucovorin in the patients with advanced colorectal carcinoma.Methods 43 cases of colorectal carcinoma were treated with continuous infusion of fluorouracl 250 mg/m 2 on days 1 to 10 with infusion of calcium lencovorin 100 mg on day 1 to 10,with infusion of oxaliplatin 130 mg/m 2 on two hours.32 cases of colorectal carcinoma were treated with traditional infusion of fluorouracl 500 mg/m 2 on days 1 to 5 with infusion of calcium lencovorin 200 mg on day 1 to 5 with infusion of oxaliplatin 130 mg/m 2 on two hours.The clinical response and the side effects were observed.Results The response rate was 48.8%(21/43)in the group with continuous infusion of fluorouracl regimen,and 25.0%(8/32)in the group with traditional infusion of fluorouracl regimen,showing a significant difference.The toxicities in the group with traditional infusion of fluorouracl were more severe than in the group with continuous infusion of fluorouracl.The toxicities were mainly myelosuppression,nausea.Conclusion Continuous infusion of fluorouracl regimen is a better method than traditional infusion in the treatment of gastric cancer.