椎动脉型颈椎病血浆ET、NO的变化

THE PLASMA ET AND NO CHANGES IN VERTEBRAL-ARTERY-TYPE CERVICAL SPONDYLOSIS

为验证研究椎动脉型颈椎病 (CSA)与血浆ET(内皮素 )、NO(一氧化氮 )的相关性 ,探讨椎动脉型颈椎病的发病机理。选典型的椎动脉型颈椎病患者 4 6例称CSA组 ,其中 2 0例合并神经根型称CSAN组 ,同时设立神经根型组 2 0例称N组 ,正常对照组 4 6例 ,分别检测各组样本血浆ET、NO水平 ,同时对 4 6例椎动脉型颈椎病患者中 8例发作期作血浆ET、NO检测。结果显示 8例椎动脉型颈椎病发作期血浆ET、NO水平远远高于其他各组 (P <0 .0 5 ) ;椎动脉型颈椎病组稳定期ET亦明显高于正常对照组 (P <0 .0 5 ) ,而NO则低于正常对照组 (P <0 .0 5 ) ;椎动脉型颈椎病合并神经根型组血浆ET高于纯神经根型组 (P <0 .0 5 ) ,NO水平低于纯神经根组 ;纯神经根型组血浆ET、NO水平与正常对照组无明显差异 (P >0 .0 5 )。表明椎动脉型颈椎病与血浆ET、NO明显相关性 ,推测血浆ET与NO可能参与了椎动脉型颈椎病的发病。

The objective of the paper is to study and verify the relation of vertebral-artery-type cervical spondylosis (CSA) to plasma ET and NO and to explore the pathogenesis of CSA. Forty-six typical CSA cases were selected as CSA group, and 20 of them were complicated with nerve-root-type symptoms and taken as CSAN group; another 20 CSA cases of pure nerve-root type were used as N group, and 46 normal volunteers were used as the normal control (C) group; the plasma ET and NO levels of all group were determined, respectively and those of 8 cases in CSA group were determined at the attack stage. The results showed: (1) the ET and NO levels of 8 cases determined at the attack stage far higher than those of other groups (P < 0.05); (2) the ET levels in CSA group at the stable stage significantly higher but the NO levels lower than those of C group (P < 0.05); and (3) the ET levels of CSAN group higher (P < 0.05) but the NO level lower than those of N group; (4) the ET and NO levels of N group had no significant difference from those of C group (P > 0.05), suggesting that CSA has a obvious relation to the plasma ET and NO levels, which could participate in CSA attack.