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前列腺素内过氧化物合酶2基因的研究进展 被引量：42

Advances on prostaglandin-endoperoxide synthase 2 gene
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摘要 前列腺素内过氧化物合酶2是前列腺素生物合成的限速酶。本文介绍了前列腺素内过氧化物合酶2基因的结构、表达、调控机理及其与繁殖性能的关系。 Prostaglandin-endoperoxide synthase 2 is the rate-limiting enzyme in the biosynthesis of prostaglandins(PGs). In this paper, we briefly introduced the structure, expression, regulation mechanism of prostaglandin-endoperoxide synthase 2 gene and the relationship between this gene and reproductive performance.
作者 王训翠 储明星 陈宏权
机构地区 安徽农业大学畜牧水产学院 中国农业科学院畜牧研究所
出处 《生命科学》 CSCD 2004年第1期31-34,共4页 Chinese Bulletin of Life Sciences
基金 国家高技术研究发展专项经费(2002AA211081)
关键词 前列腺素内过氧化物合酶2基因 调控机理 繁殖性能 prostaglandin-endoperoxide synthase 2 gene regulation mechanism reproductive performance
分类号 Q953 [生物学—动物学]
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参考文献18

  • 1Appleby S B, Ristimaki A, Neilson K, et al. Structure of the human cyclo-oxygenase-2gene. J Biochem, 1994, 302(3):723-727.
  • 2Charpigny G, Reinaud P, Tamby J P, et al. Expression of cyclooxygenase-1 and -2 in ovine endometrium during the estrous cycle and early pregnancy. Endocrinology, 1997,138(5): 2163-2171.
  • 3Morita I, Schindler M, Regier K, et al. Different Intracellular locations for prostaglandin endoperoxide H synthase-land -2. J Biol Chem, 1995, 270(18): 10902-10908.
  • 4Yokoyama C, Tanabe T. Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure.Biochem Biophys Res Commun, 1989, 165(2): 888-894.
  • 5Kosaka T, Miyata A, Ihara H, et al. Characterization of the human gene(PTGS2) encoding prostaglandin-endoperoxide synthase 2. Eur J Biochem, 1994, 221:889-897.
  • 6Sirois J, Levy L, Simmons D L, et al. Characterization and hormonal regulation of the promoter of the rat prostaglandin endoperoxide synthase 2 gene in granulose cells. Identification of functional and protein-binding regions. J Biol Chem,1993, 268(16):12199-12206.
  • 7Gladney C D, Martinez V G, Brumbaugh K A, et al.Mapping of the prostaglandin-endoperoxide synthase 2 (PTGS2) gene to porcine chromosome 9 and bovine chromosome 16 by linkage analysis using novel PCR-RFLP. J Anim Sci, 1999, 77(3): 787-788.
  • 8Sirois J, Richards J S. Purification and characterization of a novel, distinct isoform of prostaglandin endoperoxide synthase induced by human chorionic gonadotropin in granulose cells of rat preovulatory follicles. J Biol Chem, 1992, 267(9):6382-6388.
  • 9Fletcher B S, Kujubu D A, Penin D M, et al. Structure of the mitogen-induicble TIS 10 gene and demonstration that the TIS 10-encoded protein is a functional prostaglandin G/H synthase. J Biol Chem, 1992, 267(7): 4338-4344.
  • 10Boerboom D, Sirois J. Molecular characterization of equine prostaglandin G/H synthasc-2 and regulation of its messenger ribonucleic acidin preovulatory follicles. Endocrinology,1998, 139(4): 1662-1670.

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生命科学
2004年 第1期

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