摘要
目的 :探索神经元自身保护基因在苯妥英钠耐药鼠和非耐药鼠中的差异表达。方法 :选择成年Wistar大鼠用电刺激杏仁核方法建立耐PHT和非耐药癫大鼠模型 ,应用含有 4 0 96条人类全长基因的cDNA表达谱芯片 ,检测耐药与非耐药组神经元保护基因表达谱的差异。结果 :发现 10条神经元自身保护基因的表达在两组间存在差异。结论 :神经元自我保护机制的降低可能是难治性癫形成的原因之一。
Objective:To determine the differential neuron protection genes expression in drug resistant and drug responder epileptic rat model.Methods:Adult Wistar rats were seleted to prepare PHT resistant and PHT responder epilepsy model. The cDNA microarray containing four thousand and ninety six human target genes was used to determine the difference of neuron protection gene expression spectrum between drug resistant group and drug responder group.Results:Difference between PHT resistant and PHT responder epileptic rats was noted in 10 neuron protection genes.Conclusion:The decrease of neuron protection mechanism might be one of the causes of intractable epilepsy.
出处
《临床神经电生理学杂志》
2004年第1期31-34,共4页
Journal of Clinical Electroneurophysiology
基金
卫生部科学研究基金资助 (98-1-3 5 4)
重庆市卫生局科研基金资助(0 1-2 -0 3 1)
