冠心病患者外周血红蛋白含量变化的临床意义

Changes of Hb in Coronary Heart Disease Patients and its Clinical Significances

目的探讨冠心病患者外周血红蛋白含量 (Hb)变化及其临床意义。方法应用美国库尔特JT血球计数器测定Hb ,结合冠状动脉造影 (冠脉造影 )及超声心动图检查 ,观察286例冠心病患者Hb变化及其冠状动脉硬化及冠脉事件的相关性。结果冠心病患者外周血中Hb较正常对照组显著增加 (P<0.05) ,其中心肌梗死 (心梗 )组升高更明显 ,四分位法研究Hb含量位于最高1/4位者发生心梗及不稳定型心绞痛者较Hb含量位于最低1/4位者显著增加(P<0.05)。大部分心梗及不稳定型心绞痛发生在最高1/4位。冠脉造影冠心病伴冠脉闭塞组其Hb含量(150.92±12.80)g/L显著高于冠心病不伴冠脉闭塞组(139.98±13.11)g/L(P<0.05)。结论冠心病患者Hb升高可能是冠脉事件发生的潜在危险因子之一。

Objective To investigate changes and significance of Hb in patients with coronary heart dieaes(CHD).Methods286CHD Patients,average63.16±12.21years,male182cases and female104cases,were examined Hb and atherosclerotic changes were quantified by coronary arteriography.Results The Hb is significant-ly increased in CHD patients compared with control group,and increased much more in acute myocardial infarction and old myocardial infarction group.CHD events(fatal and nonfatal myocardial infarction and unstable angina pec-toris)in the highest quartile of Hb group is significantly increased in comparison with the lowest quartile of Hb group.A large proportion of events occurred among patients in the highest quintile.Correlation analysis showed that Hb correlated positively to the level of coronany artery stenosis.Conclusions These findings suggest that Hb may has considerable potential to idenfify subjects at risk for CHD events.