严重烧伤患者细胞免疫功能研究

A Study on the Cellular Immune Function in Severely Burned Patients

目的了解严重烧伤患者伤后细胞免疫状况 ,为探索烧伤患者免疫功能紊乱的发生机制提供帮助。方法动态观察35例严重烧伤患者伤后1、2、3周各细胞免疫指标的变化 ,并与10例健康献血员作对照分析。结果与对照组比较 :严重烧伤患者T细胞亚群发生明显变化 ;CD3 细胞、CD4 细胞比例下降、CD8 细胞比例升高、CD4/CD8 细胞比值下降 ,血清可溶性白介素2受体水平明显升高 ,NK细胞活性下降 ,T淋巴细胞转化活性降低。结论严重烧伤患者伤后细胞免疫功能严重受损。

Objective To investigate the state of post-burn cellular immune function and to explore the mechanisms of immune functional disorder in severely burned patients.Methods The changes of cellular im-munologlcal indices were dynamically observed in35severely burned patients in1,2,3.post-burn weeks and were compared to those in10healthy blood donators.Results Compared to those in control group:The T cell subgroup changed obviously in severely burned patients.The proportion of CD 3 、CD 4 cell of Tcell subgroup decreased,in con-comitant with the increase of the ratio of CD 8 cells and the decrease of the ratio of CD 4 /CD 8 .Serum soluble IL-2R level increased evidently.NK cell activity decreased and T lymphocyte transforming activity de-creased.Conclusions The post-burn cellular immune function was seriously impaired in severely burned patients.