支气管肺炎患儿治疗前后血清SOD、TNF和T淋巴细胞亚群检测的临床意义

Clinical Significance of Determination of Changes Serum SOD, TNF Levels and T-Cell Subgroup Distribution Type During Treatment in Pediatric Patients with Bronchopneumonia

目的 :探讨支气管肺炎患儿治疗前后血清SOD、TNF水平和T淋巴细胞亚群分布状况的改变。方法 :分别应用放射免疫分析和单克隆抗体法对 38例支气管肺炎患儿进行了血清SOD、TNF水平及T淋巴细胞亚群的检测 ,并与 35名正常健康人作比较。结果 :支气管肺炎患儿在治疗前血清SOD、T淋巴细胞CD4/CD8值水平低于正常人组 (p<0 0 1 ) ,而TNF水平则高于正常人组 (p <0 0 1 ) ,治疗后一周则与正常人组无显著性差异(p >0 0 5 )。结论 :检测支气管肺炎患儿血清SOD。

Objective To investigate the changes of serum SOD, TNF levels and T-cell subgroup distribution type during treatment in pediatric patients with bronchopneumonia. Methods Serum SOD and TNF levels were measured with RIA and T-cell subgroup distribution type was detected with monoclonal antibody before and after treatment in 38 pediatric patients with bronchopneumonia and 35 controls. Results Before treatment, the serum levels of SOD were lower and serum TNF levels were higher in the patients than those in the controls ( p <0 01). For T-cell subgroup distribution, the CD 4/CD 8 value was also significantly lower in the patients ( p <0 01). After treatment, the serum SOD, TNF levels and CD 4/CD 8 value returned to normal with no significant difference from those in the controls ( P >0 05). Conclusion Determination of serum SOD, TNF levels and T-cell subgroup distribution type is clinically useful in the management of pediatric patients with bronchopneumonia.