老年原发性高血压患者血清生长激素与胰岛素间的相关性分析

Serum Growth Hormone and Insulin Levels in Elderly Patients with Essential Hypertension

目的 :探讨老年原发性高血压 (EH)患者血清生长激素与胰岛素水平的改变、相关性及其临床意义。方法 :采用放射免疫分析测定了 88例老年原发性高血压患者和 4 0例非高血压患者的血清生长激素和胰岛素水平 ,并进行统计学分析。结果 :EH组血清生长激素水平显著低于对照组 (p <0 0 1 ) ,胰岛素显著高于对照组(p <0 0 1 ) ,两者间呈显著的正相关 (p<0 0 5 ) ,但与平均动脉压均无显著的相关性意义 (p均 >0 0 5 )。Ⅲ期组血清生长激素显著低于Ⅰ、Ⅱ期组 (p<0 0 1 ,p <0 0 5 ) ,Ⅰ、Ⅱ、Ⅲ期组间血清生长激素依次递减 ,方差检验具有显著的差异 (p <0 0 1 ) ,而胰岛素无显著差异 (p >0 0 5 )。 1、2、3级组血清生长激素与胰岛素虽依次递减 ,但无统计学意义 (p >0 0 5 )。低危组、中危组、高危组、很高危组间血清生长激素也依次递减 ,方差检验具有显著的差异 (p <0 0 1 ) ,而胰岛素无显著差异 (p >0 0 5 )。伴心脑血管并发症组血清生长激素水平显著低于无并发症组 (p <0 0 1 ) ,但胰岛素却无显著差异 (p >0 0 5 )。结论 :老年原发性高血压 (EH)患者血清生长激素水平显著低于对照组 ;Ⅲ期组血清生长激素显著低于Ⅰ、Ⅱ期组 ,Ⅰ、Ⅱ、Ⅲ期组间血清生长激素依次显著递减 ;低危组、中危组、高危组。

Objective To investigate the changes of serum growth bormone (GH) and insulin (IS) levels in elderly patients with essential hypertension (EH). Methods Serum GH and IS levels were measured with RIA in 88 elderly patietns (age 60～88) with EH and 40 normotensive controls. Results Serum levels of GH were significantly lower and serum IS levels significantly higher in EH patients than those in the controls ( t=3 769,p <0 01; t=3 726,p <0 01). The serum GH levels were significantly positively correlated to the serum IS levels ( r=0 393,p <0 05) and both were not significantly correlated to the mean anterial pressure ( p >0 05). GH levels were most markedly decreased in stage Ⅲ hypertensives and the differences in GH levels among patients of different stages (stage Ⅰ,Ⅱ,Ⅲ) were significant ( F=8 182,p <0 01) but not so with IS ( F=0 4077,p >0 05). Both the differences of GH levels and IS levels among different grades (grade 1,2,3) patients were not significant, For different rick groups (low, moderate, high, very high), the differences in GH levels were significant ( F=3 918,p <0 01), but again not so with IS ( F=0 469,p >0 05). In EH patients with heart and/or brain complications, GH levels were significantly lower than those in patients without complications ( t=3 396,p <0 01). However, IS levels in two groups were about the same. Conclusion In elderly EH patient, the serum levels of GH were significantly lower than those in the controls. The levels dropped continuously as the disease process worsened. For IS, the serum levels were higher than those in controls, but did not increase along with the disease process.