比较国产与进口复方噻吗洛尔滴眼液对家兔瞳孔和眼压的影响

Effects of domestic vs imported combined timolol-pilocarpine eye drops on pupil and intraocular pressure in rabbits

目的 :比较复方噻吗洛尔国产滴眼液 (含0 .5 %噻吗洛尔和 2 %硝酸毛果芸香碱 )和进口滴眼液 (含 0 .5 %噻吗洛尔和 2 %盐酸毛果芸香碱 )对家兔瞳孔和眼压的影响。方法 :测量正常家兔瞳孔直径变化 ,制备水负荷高眼压兔模型并用压陷式眼压计测量家兔眼压。结果 :国产和进口滴眼液在给药后 15～ 12 0min ,家兔瞳孔明显缩小 ,较对照组眼压明显下降 ,2组间无显著统计差异。结论 :含不同毛果芸香碱盐基的复方噻吗洛尔国产滴眼液与进口滴眼液均具有明显缩瞳和降眼压作用 ,其药理作用强度和作用持续时间无明显差异。

AIM: To compare the miosis and intraocular pressure (IOP) lowering effects of timolol-pilocarpine fixed-ratio combinations between domestic eyedrops (0.5 % timolol and 2 % pilocarpine nitrate) and imported eye drops (0.5 % timolol and 2 % pilocarpine hydrochloride) on pupil and intraocular pressure (IOP) in rabbits. METHODS: Normal rabbits and water laoding rabbits were used to measure the pupil diameter and IOP, respectively. RESULTS: Domestic and imported combined timolol-pilocarpine eye drops had marked miosis in normal rabbits from 15 min up to 120 min after administration. After water loading to rabbits, domestic and imported combined timolol-pilocarpine eye drops also significantly lowered the IOP from 30 to 120 min compared with the control group. The significant differences in pupil diameter and IOP were not observed between domestic and imported eye drops. CONCLUSION: Both domestic and imported combined timolol-pilocarpine eye drops containing different salt bases of pilocarpine possess significant miosis and IOP lowering effects with no differences in pharmacological potency and action duration.