三磷酸腺苷敏感性钾通道开放剂与心肌再灌注损伤

Relationship between ATP sensitive potassium channel activation and myocardial reperfusion injury

心肌缺血再灌注损伤与缺血诱发膜除极、电解质及电生理紊乱、能量代谢障碍、细胞内钙超负荷和自由基损伤有关。三磷酸腺苷 (adenosinetriphosphate ,ATP)敏感性钾通道活化 ,可使膜超极化 ,恢复紊乱的电解质 (主要是K+ 离子 )及电生理平衡 ,降低能耗 ,减轻钙超载和自由基损伤而具有心肌保护作用。

Myocardial ischemia/reperfusion injury is associated with membranous depolarization induced by ischemia, electrolyte and electrophysiological disturbance, energy metabolic disorder, intracellular Ca 2+ overload and free radical injury. Activation of K ATP channel can make membrane ultrapolarization, keep balance of electrolyte (especially K +) and electrophysiology, reduce energy consumption, and abate Ca 2+ overload and free radical injury, so that it can protect the myocardium.