摘要
目的:探讨非小细胞肺癌(non-smallcelllungcancer,NSCLC)病理组织中细胞周期蛋白D1(cyclinD1)、血管内皮生长因子(vascularendothelialgrowthfactor,VEGF)的表达及其他多因素对预后的影响。方法:采用免疫组化方法测定73例NSCLC组织和20例良性肺部疾病组织病理切片中cyclinD1和VEGF的表达情况及与3年生存率的关系。结果:73例NSCLC组织中cyclinD1和VEGF的阳性表达率分别为64.38%和71.23%,20例良性疾病组织的cyclinD1和VEGF的阳性表达率分别为15.00%和20.00%,(χ2=15.40,17.20,P<0.01)。NSCLC组织中cyclinD1和VEGF的阳性表达仅与TNM分期和有无淋巴结转移有关。cyclinD1和VEGF阳性表达的患者3年生存率均明显低于阴性表达者,P<0.05,通过Cox回归分析发现cyclinD1、VEGF、临床床分期及有无淋巴结转移可以作为独立的指标判断NSCLC患者的生存时间。结论:cyclinD1和VEGF在大多数NSCLC中呈阳性表达,它们均可影响NSCLC的生物学行为和预后。
AIM:To investigate the expressions of cyclinD1 and vascular endothelial growth factor(VEGF) in non small cell lung cancer(NSCLC),and to explore the influence of the two biological factors and other clinical factors on prognosis of NSCLC. METHODS:Immunohistochemistry was used to detect the expressions of cyclinD1 and VEGF in pathological tissue section of 73 cases NSCLC and 20 cases non malignant tissue from lung lesions,and study the relationship of expressions of cyclinD1 and VEGF with survival rate of three years in NSCLC. RESULTS:The expression rates of cyclinD1 and VEGF in NSCLC were 64.38% and 71.23% respectively,but in non malignant tissue from lung lesions,they were 15.00% and 20.00% respectively(χ2=15.40,17.20,P< 0.01).The positive expressions of the cyclinD1 and VEGF in NSCLC was related only to TNM stages and metastasis of lymph nodes.Survival rates of three years in patients with positive expressions of the two biological factors were lower than those with the negative expressions(P< 0.05).By Cox regression analysis,cyclinD1,VEGF,TNM stages and the metastasis of lymph nodes were the independent prognostic factors that measured the survival time of patients with NSCLC. CONCLUSION:Positive expressions of cyclinD1 and VEGF occur in most NSCLC,which may affect prognosis of NSCLC,but only TNM stages and the metastasis of lymph nodes may affect the prognosis of NSCLC in many clinical factors.
出处
《中国临床康复》
CSCD
2004年第5期898-899,共2页
Chinese Journal of Clinical Rehabilitation
